The Inner and Outer Qualities of Extracellular Vesicles for Translational Purposes in Breast Cancer

Breast cancer (BC) is the second most common cause of cancer mortality of women worldwide. BC is a systemic disease with a highly heterogeneous course of disease. Therefore, prognostic and diagnostic biomarkers are required to improve the clinical risk management. Cancer-derived or cancer-associated...

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Detalles Bibliográficos
Autores principales: Schwich, Esther, Rebmann, Vera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879062/
https://www.ncbi.nlm.nih.gov/pubmed/29632535
http://dx.doi.org/10.3389/fimmu.2018.00584
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author Schwich, Esther
Rebmann, Vera
author_facet Schwich, Esther
Rebmann, Vera
author_sort Schwich, Esther
collection PubMed
description Breast cancer (BC) is the second most common cause of cancer mortality of women worldwide. BC is a systemic disease with a highly heterogeneous course of disease. Therefore, prognostic and diagnostic biomarkers are required to improve the clinical risk management. Cancer-derived or cancer-associated extracellular vesicles (EVs) procured from the bloodstream of BC patients offer a novel platform for the qualitative and quantitative screening and establishment of biomarkers. Here, we focus on common aspects of EVs, on the function of BC-derived EVs and their translational potential considering the EV abundancy, intravesicular as well as outer membrane-anchored composition and current challenges of implementation in clinical practice.
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spelling pubmed-58790622018-04-09 The Inner and Outer Qualities of Extracellular Vesicles for Translational Purposes in Breast Cancer Schwich, Esther Rebmann, Vera Front Immunol Immunology Breast cancer (BC) is the second most common cause of cancer mortality of women worldwide. BC is a systemic disease with a highly heterogeneous course of disease. Therefore, prognostic and diagnostic biomarkers are required to improve the clinical risk management. Cancer-derived or cancer-associated extracellular vesicles (EVs) procured from the bloodstream of BC patients offer a novel platform for the qualitative and quantitative screening and establishment of biomarkers. Here, we focus on common aspects of EVs, on the function of BC-derived EVs and their translational potential considering the EV abundancy, intravesicular as well as outer membrane-anchored composition and current challenges of implementation in clinical practice. Frontiers Media S.A. 2018-03-26 /pmc/articles/PMC5879062/ /pubmed/29632535 http://dx.doi.org/10.3389/fimmu.2018.00584 Text en Copyright © 2018 Schwich and Rebmann. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Schwich, Esther
Rebmann, Vera
The Inner and Outer Qualities of Extracellular Vesicles for Translational Purposes in Breast Cancer
title The Inner and Outer Qualities of Extracellular Vesicles for Translational Purposes in Breast Cancer
title_full The Inner and Outer Qualities of Extracellular Vesicles for Translational Purposes in Breast Cancer
title_fullStr The Inner and Outer Qualities of Extracellular Vesicles for Translational Purposes in Breast Cancer
title_full_unstemmed The Inner and Outer Qualities of Extracellular Vesicles for Translational Purposes in Breast Cancer
title_short The Inner and Outer Qualities of Extracellular Vesicles for Translational Purposes in Breast Cancer
title_sort inner and outer qualities of extracellular vesicles for translational purposes in breast cancer
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879062/
https://www.ncbi.nlm.nih.gov/pubmed/29632535
http://dx.doi.org/10.3389/fimmu.2018.00584
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