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Identification of Minimal p53 Promoter Region Regulated by MALAT1 in Human Lung Adenocarcinoma Cells

The MALAT1 long noncoding RNA is strongly linked to cancer progression. Here we report a MALAT1 function in repressing the promoter of p53 (TP53) tumor suppressor gene. p21 and FAS, well-known p53 targets, were upregulated by MALAT1 knockdown in A549 human lung adenocarcinoma cells. We found that th...

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Detalles Bibliográficos
Autores principales:	Tano, Keiko, Onoguchi-Mizutani, Rena, Yeasmin, Fouzia, Uchiumi, Fumiaki, Suzuki, Yutaka, Yada, Tetsushi, Akimitsu, Nobuyoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879451/ https://www.ncbi.nlm.nih.gov/pubmed/29632545 http://dx.doi.org/10.3389/fgene.2017.00208

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