Synthesis and Characterization of a Bidirectional Photoswitchable Antagonist Toolbox for Real-Time GPCR Photopharmacology

[Image: see text] Noninvasive methods to modulate G protein-coupled receptors (GPCRs) with temporal and spatial precision are in great demand. Photopharmacology uses photons to control in situ the biological properties of photoswitchable small-molecule ligands, which bodes well for chemical biologic...

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Detalles Bibliográficos
Autores principales: Hauwert, Niels J., Mocking, Tamara A. M., Da Costa Pereira, Daniel, Kooistra, Albert J., Wijnen, Lisa M., Vreeker, Gerda C. M., Verweij, Eléonore W. E., De Boer, Albertus H., Smit, Martine J., De Graaf, Chris, Vischer, Henry F., de Esch, Iwan J. P., Wijtmans, Maikel, Leurs, Rob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879491/
https://www.ncbi.nlm.nih.gov/pubmed/29470065
http://dx.doi.org/10.1021/jacs.7b11422

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