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Pregnancy and Cardiomyopathy After Anthracyclines in Childhood
With advances in cancer therapy, there has been a remarkable increase in survival in children diagnosed with malignancies. Many of these children are treated with anthracyclines which are well known to cause cardiotoxicity. As more childhood cancer survivors reach childbearing age, many will choose...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879537/ https://www.ncbi.nlm.nih.gov/pubmed/29632865 http://dx.doi.org/10.3389/fcvm.2018.00014 |
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author | Thompson, Kara Annette |
author_facet | Thompson, Kara Annette |
author_sort | Thompson, Kara Annette |
collection | PubMed |
description | With advances in cancer therapy, there has been a remarkable increase in survival in children diagnosed with malignancies. Many of these children are treated with anthracyclines which are well known to cause cardiotoxicity. As more childhood cancer survivors reach childbearing age, many will choose to become pregnant. At this time, the factors associated with development of cardiomyopathy after anthracycline treatment are not clearly identified. It is possible that cardiac stress could predispose to cardiac deterioration in a patient with reduced functional reserve from prior anthracycline exposure. Pregnancy is one form of cardiovascular stress. The cardiac outcomes of pregnancy in childhood cancer survivors must be considered. In view of limited data, guidelines for pregnancy planning, management, and monitoring after cardiotoxic cancer therapy have not been established. This review summarizes the limited data available on the topic of pregnancy after anthracyclines in childhood. |
format | Online Article Text |
id | pubmed-5879537 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-58795372018-04-09 Pregnancy and Cardiomyopathy After Anthracyclines in Childhood Thompson, Kara Annette Front Cardiovasc Med Cardiovascular Medicine With advances in cancer therapy, there has been a remarkable increase in survival in children diagnosed with malignancies. Many of these children are treated with anthracyclines which are well known to cause cardiotoxicity. As more childhood cancer survivors reach childbearing age, many will choose to become pregnant. At this time, the factors associated with development of cardiomyopathy after anthracycline treatment are not clearly identified. It is possible that cardiac stress could predispose to cardiac deterioration in a patient with reduced functional reserve from prior anthracycline exposure. Pregnancy is one form of cardiovascular stress. The cardiac outcomes of pregnancy in childhood cancer survivors must be considered. In view of limited data, guidelines for pregnancy planning, management, and monitoring after cardiotoxic cancer therapy have not been established. This review summarizes the limited data available on the topic of pregnancy after anthracyclines in childhood. Frontiers Media S.A. 2018-03-26 /pmc/articles/PMC5879537/ /pubmed/29632865 http://dx.doi.org/10.3389/fcvm.2018.00014 Text en Copyright © 2018 Thompson http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Thompson, Kara Annette Pregnancy and Cardiomyopathy After Anthracyclines in Childhood |
title | Pregnancy and Cardiomyopathy After Anthracyclines in Childhood |
title_full | Pregnancy and Cardiomyopathy After Anthracyclines in Childhood |
title_fullStr | Pregnancy and Cardiomyopathy After Anthracyclines in Childhood |
title_full_unstemmed | Pregnancy and Cardiomyopathy After Anthracyclines in Childhood |
title_short | Pregnancy and Cardiomyopathy After Anthracyclines in Childhood |
title_sort | pregnancy and cardiomyopathy after anthracyclines in childhood |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879537/ https://www.ncbi.nlm.nih.gov/pubmed/29632865 http://dx.doi.org/10.3389/fcvm.2018.00014 |
work_keys_str_mv | AT thompsonkaraannette pregnancyandcardiomyopathyafteranthracyclinesinchildhood |