Cargando…

Pregnancy and Cardiomyopathy After Anthracyclines in Childhood

With advances in cancer therapy, there has been a remarkable increase in survival in children diagnosed with malignancies. Many of these children are treated with anthracyclines which are well known to cause cardiotoxicity. As more childhood cancer survivors reach childbearing age, many will choose...

Descripción completa

Detalles Bibliográficos
Autor principal: Thompson, Kara Annette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879537/
https://www.ncbi.nlm.nih.gov/pubmed/29632865
http://dx.doi.org/10.3389/fcvm.2018.00014
_version_ 1783311014778896384
author Thompson, Kara Annette
author_facet Thompson, Kara Annette
author_sort Thompson, Kara Annette
collection PubMed
description With advances in cancer therapy, there has been a remarkable increase in survival in children diagnosed with malignancies. Many of these children are treated with anthracyclines which are well known to cause cardiotoxicity. As more childhood cancer survivors reach childbearing age, many will choose to become pregnant. At this time, the factors associated with development of cardiomyopathy after anthracycline treatment are not clearly identified. It is possible that cardiac stress could predispose to cardiac deterioration in a patient with reduced functional reserve from prior anthracycline exposure. Pregnancy is one form of cardiovascular stress. The cardiac outcomes of pregnancy in childhood cancer survivors must be considered. In view of limited data, guidelines for pregnancy planning, management, and monitoring after cardiotoxic cancer therapy have not been established. This review summarizes the limited data available on the topic of pregnancy after anthracyclines in childhood.
format Online
Article
Text
id pubmed-5879537
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-58795372018-04-09 Pregnancy and Cardiomyopathy After Anthracyclines in Childhood Thompson, Kara Annette Front Cardiovasc Med Cardiovascular Medicine With advances in cancer therapy, there has been a remarkable increase in survival in children diagnosed with malignancies. Many of these children are treated with anthracyclines which are well known to cause cardiotoxicity. As more childhood cancer survivors reach childbearing age, many will choose to become pregnant. At this time, the factors associated with development of cardiomyopathy after anthracycline treatment are not clearly identified. It is possible that cardiac stress could predispose to cardiac deterioration in a patient with reduced functional reserve from prior anthracycline exposure. Pregnancy is one form of cardiovascular stress. The cardiac outcomes of pregnancy in childhood cancer survivors must be considered. In view of limited data, guidelines for pregnancy planning, management, and monitoring after cardiotoxic cancer therapy have not been established. This review summarizes the limited data available on the topic of pregnancy after anthracyclines in childhood. Frontiers Media S.A. 2018-03-26 /pmc/articles/PMC5879537/ /pubmed/29632865 http://dx.doi.org/10.3389/fcvm.2018.00014 Text en Copyright © 2018 Thompson http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Thompson, Kara Annette
Pregnancy and Cardiomyopathy After Anthracyclines in Childhood
title Pregnancy and Cardiomyopathy After Anthracyclines in Childhood
title_full Pregnancy and Cardiomyopathy After Anthracyclines in Childhood
title_fullStr Pregnancy and Cardiomyopathy After Anthracyclines in Childhood
title_full_unstemmed Pregnancy and Cardiomyopathy After Anthracyclines in Childhood
title_short Pregnancy and Cardiomyopathy After Anthracyclines in Childhood
title_sort pregnancy and cardiomyopathy after anthracyclines in childhood
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879537/
https://www.ncbi.nlm.nih.gov/pubmed/29632865
http://dx.doi.org/10.3389/fcvm.2018.00014
work_keys_str_mv AT thompsonkaraannette pregnancyandcardiomyopathyafteranthracyclinesinchildhood