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Angiolymphoid hyperplasia with eosinophilia: a case report
BACKGROUND: Angiolymphoid hyperplasia with eosinophilia is a benign neoplasm that includes blood vessel proliferation and a dense eosinophilic inflammatory infiltrate. Mostly, it affects middle-aged adults manifesting as flesh/plum-colored pruritic nodules and papules, most commonly affecting the ea...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879596/ https://www.ncbi.nlm.nih.gov/pubmed/29606120 http://dx.doi.org/10.1186/s13256-018-1599-x |
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author | Youssef, Alexey Hasan, Ali Ramez Youssef, Youssef Al-soufi, Lina Elshimali, Yahya Alshehabi, Zuheir |
author_facet | Youssef, Alexey Hasan, Ali Ramez Youssef, Youssef Al-soufi, Lina Elshimali, Yahya Alshehabi, Zuheir |
author_sort | Youssef, Alexey |
collection | PubMed |
description | BACKGROUND: Angiolymphoid hyperplasia with eosinophilia is a benign neoplasm that includes blood vessel proliferation and a dense eosinophilic inflammatory infiltrate. Mostly, it affects middle-aged adults manifesting as flesh/plum-colored pruritic nodules and papules, most commonly affecting the ear and the periauricular area. CASE PRESENTATION: In this case, we report a 13-year-old Caucasian girl with bilateral, huge, protruding, and yellowish nostril masses which were peculiar in location and of gross appearance. At first, the disease proved to be a diagnostic dilemma. After making a diagnosis of angiolymphoid hyperplasia with eosinophilia, the disease also proved to be a therapeutic dilemma. It did not respond to oral prednisolone or to oral indomethacin, and it proved to be resistant to topical steroids. Although surgery is the standard therapeutic approach, it recurred despite multiple surgical attempts. However, the only regimen that seemed to partially control the lesion was intralesional steroids combined with topical tacrolimus ointment. CONCLUSIONS: Angiolymphoid hyperplasia with eosinophilia proves a therapeutic dilemma, because there is a large variety of proposed treatments, yet there is not enough data on most of them. Although the disease is not deadly by itself, it usually presents with disfiguring lesions that grimly affect the patient’s quality of life. This warrants further research and efforts to find an effective cure and a unified therapeutic approach. |
format | Online Article Text |
id | pubmed-5879596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-58795962018-04-04 Angiolymphoid hyperplasia with eosinophilia: a case report Youssef, Alexey Hasan, Ali Ramez Youssef, Youssef Al-soufi, Lina Elshimali, Yahya Alshehabi, Zuheir J Med Case Rep Case Report BACKGROUND: Angiolymphoid hyperplasia with eosinophilia is a benign neoplasm that includes blood vessel proliferation and a dense eosinophilic inflammatory infiltrate. Mostly, it affects middle-aged adults manifesting as flesh/plum-colored pruritic nodules and papules, most commonly affecting the ear and the periauricular area. CASE PRESENTATION: In this case, we report a 13-year-old Caucasian girl with bilateral, huge, protruding, and yellowish nostril masses which were peculiar in location and of gross appearance. At first, the disease proved to be a diagnostic dilemma. After making a diagnosis of angiolymphoid hyperplasia with eosinophilia, the disease also proved to be a therapeutic dilemma. It did not respond to oral prednisolone or to oral indomethacin, and it proved to be resistant to topical steroids. Although surgery is the standard therapeutic approach, it recurred despite multiple surgical attempts. However, the only regimen that seemed to partially control the lesion was intralesional steroids combined with topical tacrolimus ointment. CONCLUSIONS: Angiolymphoid hyperplasia with eosinophilia proves a therapeutic dilemma, because there is a large variety of proposed treatments, yet there is not enough data on most of them. Although the disease is not deadly by itself, it usually presents with disfiguring lesions that grimly affect the patient’s quality of life. This warrants further research and efforts to find an effective cure and a unified therapeutic approach. BioMed Central 2018-04-02 /pmc/articles/PMC5879596/ /pubmed/29606120 http://dx.doi.org/10.1186/s13256-018-1599-x Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Youssef, Alexey Hasan, Ali Ramez Youssef, Youssef Al-soufi, Lina Elshimali, Yahya Alshehabi, Zuheir Angiolymphoid hyperplasia with eosinophilia: a case report |
title | Angiolymphoid hyperplasia with eosinophilia: a case report |
title_full | Angiolymphoid hyperplasia with eosinophilia: a case report |
title_fullStr | Angiolymphoid hyperplasia with eosinophilia: a case report |
title_full_unstemmed | Angiolymphoid hyperplasia with eosinophilia: a case report |
title_short | Angiolymphoid hyperplasia with eosinophilia: a case report |
title_sort | angiolymphoid hyperplasia with eosinophilia: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879596/ https://www.ncbi.nlm.nih.gov/pubmed/29606120 http://dx.doi.org/10.1186/s13256-018-1599-x |
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