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CHRNA5 and CHRNA3 polymorphism and lung cancer susceptibility in Palestinian population
OBJECTIVE: The genetic polymorphism (rs16969968 in CHRNA5, and rs1051730 in CHRNA3 genes) were recently shown to be associated with risk of LC. The aim of this study is to elucidate whether they predispose Palestinian individuals to lung cancer, and how is this related to smoking. RESULTS: Frequency...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879790/ https://www.ncbi.nlm.nih.gov/pubmed/29609626 http://dx.doi.org/10.1186/s13104-018-3310-0 |
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author | Ayesh, Basim Mohammad Al-Masri, Rami Abed, Abdalla Assaf |
author_facet | Ayesh, Basim Mohammad Al-Masri, Rami Abed, Abdalla Assaf |
author_sort | Ayesh, Basim Mohammad |
collection | PubMed |
description | OBJECTIVE: The genetic polymorphism (rs16969968 in CHRNA5, and rs1051730 in CHRNA3 genes) were recently shown to be associated with risk of LC. The aim of this study is to elucidate whether they predispose Palestinian individuals to lung cancer, and how is this related to smoking. RESULTS: Frequency of the rs16969968-A allele was significantly higher in the case group (36.7%) than in normal controls (17.5%; P = 0.022; OR = 6.83 for AA and 2.81 for AG genotypes). The frequency of rs1051730-T allele was also significantly higher in the case group (46.7%) than in the control group (22.5%; P = 0.001; OR = 2.20 for TC and 13.22 for TT genotypes). Frequency of rs16969968-A allele was higher in smokers (29.1%) than nonsmokers (15.7%) regardless of lung cancer; similarly, frequency of rs1051730-T allele was also higher in smokers than in smokers (46.7% vs 22.5%, respectively). The higher the proportion of the risk allele (rs16969968-A and rs1051730-T), the higher the mean number of daily consumed cigarettes (P = 0.006). Carrying rs16969968-A and/or rs1051730-T alleles results in an increased risk to lung cancer probably by increasing the individual’s tendency for heavy smoking. The allelic frequency of the rs16969968-A and rs1051730-T alleles among normal Palestinian controls is similar to different populations worldwide. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13104-018-3310-0) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5879790 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-58797902018-04-04 CHRNA5 and CHRNA3 polymorphism and lung cancer susceptibility in Palestinian population Ayesh, Basim Mohammad Al-Masri, Rami Abed, Abdalla Assaf BMC Res Notes Research Note OBJECTIVE: The genetic polymorphism (rs16969968 in CHRNA5, and rs1051730 in CHRNA3 genes) were recently shown to be associated with risk of LC. The aim of this study is to elucidate whether they predispose Palestinian individuals to lung cancer, and how is this related to smoking. RESULTS: Frequency of the rs16969968-A allele was significantly higher in the case group (36.7%) than in normal controls (17.5%; P = 0.022; OR = 6.83 for AA and 2.81 for AG genotypes). The frequency of rs1051730-T allele was also significantly higher in the case group (46.7%) than in the control group (22.5%; P = 0.001; OR = 2.20 for TC and 13.22 for TT genotypes). Frequency of rs16969968-A allele was higher in smokers (29.1%) than nonsmokers (15.7%) regardless of lung cancer; similarly, frequency of rs1051730-T allele was also higher in smokers than in smokers (46.7% vs 22.5%, respectively). The higher the proportion of the risk allele (rs16969968-A and rs1051730-T), the higher the mean number of daily consumed cigarettes (P = 0.006). Carrying rs16969968-A and/or rs1051730-T alleles results in an increased risk to lung cancer probably by increasing the individual’s tendency for heavy smoking. The allelic frequency of the rs16969968-A and rs1051730-T alleles among normal Palestinian controls is similar to different populations worldwide. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13104-018-3310-0) contains supplementary material, which is available to authorized users. BioMed Central 2018-04-02 /pmc/articles/PMC5879790/ /pubmed/29609626 http://dx.doi.org/10.1186/s13104-018-3310-0 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Note Ayesh, Basim Mohammad Al-Masri, Rami Abed, Abdalla Assaf CHRNA5 and CHRNA3 polymorphism and lung cancer susceptibility in Palestinian population |
title | CHRNA5 and CHRNA3 polymorphism and lung cancer susceptibility in Palestinian population |
title_full | CHRNA5 and CHRNA3 polymorphism and lung cancer susceptibility in Palestinian population |
title_fullStr | CHRNA5 and CHRNA3 polymorphism and lung cancer susceptibility in Palestinian population |
title_full_unstemmed | CHRNA5 and CHRNA3 polymorphism and lung cancer susceptibility in Palestinian population |
title_short | CHRNA5 and CHRNA3 polymorphism and lung cancer susceptibility in Palestinian population |
title_sort | chrna5 and chrna3 polymorphism and lung cancer susceptibility in palestinian population |
topic | Research Note |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879790/ https://www.ncbi.nlm.nih.gov/pubmed/29609626 http://dx.doi.org/10.1186/s13104-018-3310-0 |
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