Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells

BACKGROUND: Mounting evidence suggests that one of the ways that cells adapt to hypoxia is through alternative splicing. The aim of this study was firstly to examine the effect of hypoxia on the alternative splicing of cancer associated genes using the prostate cancer cell line PC3 as a model. Secon...

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Detalles Bibliográficos
Autores principales: Bowler, Elizabeth, Porazinski, Sean, Uzor, Simon, Thibault, Philippe, Durand, Mathieu, Lapointe, Elvy, Rouschop, Kasper M. A., Hancock, John, Wilson, Ian, Ladomery, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879922/
https://www.ncbi.nlm.nih.gov/pubmed/29606096
http://dx.doi.org/10.1186/s12885-018-4227-7

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