Dynamics of DNMT3A mutation and prognostic relevance in patients with primary myelodysplastic syndrome

BACKGROUND: DNMT3A gene mutation has been associated with poor prognosis in acute myeloid leukemia, but its clinical implications in myelodysplastic syndrome (MDS) and dynamic changes during disease progression remain controversial. RESULTS: In this study, DNMT3A mutation was identified in 7.9% of 4...

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Detalles Bibliográficos
Autores principales: Lin, Ming-En, Hou, Hsin-An, Tsai, Cheng-Hong, Wu, Shang-Ju, Kuo, Yuan-Yeh, Tseng, Mei-Hsuan, Liu, Ming-Chih, Liu, Chia-Wen, Chou, Wen-Chien, Chen, Chien-Yuan, Tang, Jih-Luh, Yao, Ming, Li, Chi-Cheng, Huang, Shang-Yi, Ko, Bor-Sheng, Hsu, Szu-Chun, Lin, Chien-Ting, Tien, Hwei-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879939/
https://www.ncbi.nlm.nih.gov/pubmed/29619119
http://dx.doi.org/10.1186/s13148-018-0476-1

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