The identification of H3F3A mutation in giant cell tumour of the clivus and the histological diagnostic algorithm of other clival lesions permit the differential diagnosis in this location

BACKGROUND: Giant Cell Tumour of Bone (GCT) is a locally aggressive primary bone tumour that usually occurs at the epiphyses of the long bones of the appendicular skeleton with a tendency to recurrence. Recurrent somatic H3F3A mutations have been described in 92% of GCT cases. GCTs involving the Cli...

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Detalles Bibliográficos
Autores principales: Scotto di Carlo, Federica, Divisato, Giuseppina, Iacoangeli, Maurizio, Esposito, Teresa, Gianfrancesco, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880014/
https://www.ncbi.nlm.nih.gov/pubmed/29609578
http://dx.doi.org/10.1186/s12885-018-4291-z

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