The Sequence-specific Peptide-binding Activity of the Protein Sulfide Isomerase AGR2 Directs Its Stable Binding to the Oncogenic Receptor EpCAM

AGR2 is an oncogenic endoplasmic reticulum (ER)-resident protein disulfide isomerase. AGR2 protein has a relatively unique property for a chaperone in that it can bind sequence-specifically to a specific peptide motif (TTIYY). A synthetic TTIYY-containing peptide column was used to affinity-purify A...

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Detalles Bibliográficos
Autores principales: Mohtar, M. Aiman, Hernychova, Lenka, O'Neill, J. Robert, Lawrence, Melanie L., Murray, Euan, Vojtesek, Borek, Hupp, Ted R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880107/
https://www.ncbi.nlm.nih.gov/pubmed/29339412
http://dx.doi.org/10.1074/mcp.RA118.000573

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