Cancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations

The cancer-risk-associated rs6983267 single nucleotide polymorphism (SNP) and the accompanying long noncoding RNA CCAT2 in the highly amplified 8q24.21 region have been implicated in cancer predisposition, although causality has not been established. Here, using allele-specific CCAT2 transgenic mice...

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Autores principales: Shah, Maitri Y., Ferracin, Manuela, Pileczki, Valentina, Chen, Baoqing, Redis, Roxana, Fabris, Linda, Zhang, Xinna, Ivan, Cristina, Shimizu, Masayoshi, Rodriguez-Aguayo, Cristian, Dragomir, Mihnea, Van Roosbroeck, Katrien, Almeida, Maria Ines, Ciccone, Maria, Nedelcu, Daniela, Cortez, Maria Angelica, Manshouri, Taghi, Calin, Steliana, Muftuoglu, Muharrem, Banerjee, Pinaki P., Badiwi, Mustafa H., Parker-Thornburg, Jan, Multani, Asha, Welsh, James William, Estecio, Marcos Roberto, Ling, Hui, Tomuleasa, Ciprian, Dima, Delia, Yang, Hui, Alvarez, Hector, You, M. James, Radovich, Milan, Shpall, Elizabeth, Fabbri, Muller, Rezvani, Katy, Girnita, Leonard, Berindan-Neagoe, Ioana, Maitra, Anirban, Verstovsek, Srdan, Fodde, Riccardo, Bueso-Ramos, Carlos, Gagea, Mihai, Manero, Guillermo Garcia, Calin, George A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880235/
https://www.ncbi.nlm.nih.gov/pubmed/29567676
http://dx.doi.org/10.1101/gr.225128.117

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