Identification of novel MECOM gene fusion and personalized therapeutic targets through integrative clinical sequencing in secondary acute myeloid leukemia in a patient with severe congenital neutropenia: a case report and literature review

Severe congenital neutropenia (SCN) is a rare hematologic disorder characterized by defective myelopoiesis and a high incidence of malignant transformation to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). SCN patients who develop MDS/AML have excessive toxicities to traditional ch...

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Detalles Bibliográficos
Autores principales: Connelly, James A., Mody, Rajen J., Wu, Yi-Mi, Robinson, Dan R., Lonigro, Robert J., Vats, Pankaj, Rabban, Erica, Anderson, Bailey, Walkovich, Kelly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880254/
https://www.ncbi.nlm.nih.gov/pubmed/29572239
http://dx.doi.org/10.1101/mcs.a002204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880254/
https://www.ncbi.nlm.nih.gov/pubmed/29572239
http://dx.doi.org/10.1101/mcs.a002204

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