Noninflammatory Changes of Microglia Are Sufficient to Cause Epilepsy

Microglia are well known to play a critical role in maintaining brain homeostasis. However, their role in epileptogenesis has yet to be determined. Here, we demonstrate that elevated mTOR signaling in mouse microglia leads to phenotypic changes, including an amoeboid-like morphology, increased proli...

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Detalles Bibliográficos
Autores principales: Zhao, Xiaofeng, Liao, Yuan, Morgan, Shannon, Mathur, Ramkumar, Feustel, Paul, Mazurkiewicz, Joseph, Qian, Jiang, Chang, Julia, Mathern, Gary W., Adamo, Matthew A., Ritaccio, Anthony L., Gruenthal, Michael, Zhu, Xinjun, Huang, Yunfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880308/
https://www.ncbi.nlm.nih.gov/pubmed/29466735
http://dx.doi.org/10.1016/j.celrep.2018.02.004

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