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Development and properties of duplex MgF(2)/PCL coatings on biodegradable magnesium alloy for biomedical applications

The present work addresses the performance of polycaprolactone (PCL) coating on fluoride treated (MgF(2)) biodegradable ZK60 magnesium alloy (Mg) for biomedical application. MgF(2) conversion layer was first produced by immersing Mg alloy substrate in hydrofluoric acid solution. The outer PCL coatin...

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Detalles Bibliográficos
Autores principales: Makkar, Preeti, Kang, Hoe Jin, Padalhin, Andrew R., Park, Ihho, Moon, Byoung-Gi, Lee, Byong Taek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880343/
https://www.ncbi.nlm.nih.gov/pubmed/29608572
http://dx.doi.org/10.1371/journal.pone.0193927
Descripción
Sumario:The present work addresses the performance of polycaprolactone (PCL) coating on fluoride treated (MgF(2)) biodegradable ZK60 magnesium alloy (Mg) for biomedical application. MgF(2) conversion layer was first produced by immersing Mg alloy substrate in hydrofluoric acid solution. The outer PCL coating was then prepared using dip coating technique. Morphology, elements profile, phase structure, roughness, mechanical properties, invitro corrosion, and biocompatibility of duplex MgF(2)/PCL coating were then characterized and compared to those of fluoride coated and uncoated Mg samples. The invivo degradation behavior and biocompatibility of duplex MgF(2)/PCL coating with respect to ZK60 Mg alloy were also studied using rabbit model for 2 weeks. SEM and TEM analysis showed that the duplex coating was uniform and comprised of porous PCL film (~3.3 μm) as upper layer with compact MgF(2) (~2.2 μm) as inner layer. No significant change in microhardness was found on duplex coating compared with uncoated ZK60 Mg alloy. The duplex coating showed improved invitro corrosion resistance than single layered MgF(2) or uncoated alloy samples. The duplex coating also resulted in better cell viability, cell adhesion, and cell proliferation compared to fluoride coated or uncoated alloy. Preliminary invivo studies indicated that duplex MgF(2)/PCL coating reduced the degradation rate of ZK60 Mg alloy and exhibited good biocompatibility. These results suggested that duplex MgF(2)/PCL coating on magnesium alloy might have great potential for orthopedic applications.