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Correlation between cognitive impairment during the acute phase of first cerebral infarction and development of long-term pseudobulbar affect
PURPOSE: The relationship between cognitive impairment during the acute phase of first cerebral infarction and the development of long-term pseudobulbar affect (PBA) has not been elucidated. Therefore, in this study, we aimed to determine if cognitive impairment during the acute phase of cerebral in...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880411/ https://www.ncbi.nlm.nih.gov/pubmed/29636612 http://dx.doi.org/10.2147/NDT.S161792 |
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author | Wang, Yuan Wang, Yuliang Ma, Wenbin Lu, Shujun Chen, Jinbo Cao, Lili |
author_facet | Wang, Yuan Wang, Yuliang Ma, Wenbin Lu, Shujun Chen, Jinbo Cao, Lili |
author_sort | Wang, Yuan |
collection | PubMed |
description | PURPOSE: The relationship between cognitive impairment during the acute phase of first cerebral infarction and the development of long-term pseudobulbar affect (PBA) has not been elucidated. Therefore, in this study, we aimed to determine if cognitive impairment during the acute phase of cerebral infarction will increase the risk of long-term post-infarction PBA. PATIENTS AND METHODS: This was a nested case–control study using a prospective approach. A consecutive multicenter matched 1:1 case–control study of cognitive impairment cases following acute cerebral infarction (N=26) with 26 sex-, education years-, and age-matched controls. Univariate and multivariate conditional logistic regression analyses were performed to study the clinical features and changes in cognitive domain as well as the risk factors for PBA. RESULTS: Long-term PBA was independently predicted by low Montreal cognitive assessment (MoCA) scores at baseline. Multivariable regression models showed that post-infarction low MoCA scores remained independent predictors of long-term PBA (odds ratio [OR]=0.72; 95% confidence interval [CI]=0.54–0.95; P=0.018). Among all cognitive disorders, digit span test (DST) scores (OR=0.39; 95% CI=0.16–0.91, P=0.030), StroopC time (OR=1.15; 95% CI=1.01–1.31; P=0.037), and clock-drawing task (CDT) scores (OR=0.62; 95% CI=0.42–0.90; P=0.013) were found to be the independent risk factors for PBA. CONCLUSION: Cognitive impairment during the acute phase of cerebral infarction increased the risk of cerebral infarction-induced long-term PBA. Development of PBA was closely associated with executive function, attention, and visuospatial disorder. |
format | Online Article Text |
id | pubmed-5880411 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-58804112018-04-10 Correlation between cognitive impairment during the acute phase of first cerebral infarction and development of long-term pseudobulbar affect Wang, Yuan Wang, Yuliang Ma, Wenbin Lu, Shujun Chen, Jinbo Cao, Lili Neuropsychiatr Dis Treat Original Research PURPOSE: The relationship between cognitive impairment during the acute phase of first cerebral infarction and the development of long-term pseudobulbar affect (PBA) has not been elucidated. Therefore, in this study, we aimed to determine if cognitive impairment during the acute phase of cerebral infarction will increase the risk of long-term post-infarction PBA. PATIENTS AND METHODS: This was a nested case–control study using a prospective approach. A consecutive multicenter matched 1:1 case–control study of cognitive impairment cases following acute cerebral infarction (N=26) with 26 sex-, education years-, and age-matched controls. Univariate and multivariate conditional logistic regression analyses were performed to study the clinical features and changes in cognitive domain as well as the risk factors for PBA. RESULTS: Long-term PBA was independently predicted by low Montreal cognitive assessment (MoCA) scores at baseline. Multivariable regression models showed that post-infarction low MoCA scores remained independent predictors of long-term PBA (odds ratio [OR]=0.72; 95% confidence interval [CI]=0.54–0.95; P=0.018). Among all cognitive disorders, digit span test (DST) scores (OR=0.39; 95% CI=0.16–0.91, P=0.030), StroopC time (OR=1.15; 95% CI=1.01–1.31; P=0.037), and clock-drawing task (CDT) scores (OR=0.62; 95% CI=0.42–0.90; P=0.013) were found to be the independent risk factors for PBA. CONCLUSION: Cognitive impairment during the acute phase of cerebral infarction increased the risk of cerebral infarction-induced long-term PBA. Development of PBA was closely associated with executive function, attention, and visuospatial disorder. Dove Medical Press 2018-03-28 /pmc/articles/PMC5880411/ /pubmed/29636612 http://dx.doi.org/10.2147/NDT.S161792 Text en © 2018 Wang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Wang, Yuan Wang, Yuliang Ma, Wenbin Lu, Shujun Chen, Jinbo Cao, Lili Correlation between cognitive impairment during the acute phase of first cerebral infarction and development of long-term pseudobulbar affect |
title | Correlation between cognitive impairment during the acute phase of first cerebral infarction and development of long-term pseudobulbar affect |
title_full | Correlation between cognitive impairment during the acute phase of first cerebral infarction and development of long-term pseudobulbar affect |
title_fullStr | Correlation between cognitive impairment during the acute phase of first cerebral infarction and development of long-term pseudobulbar affect |
title_full_unstemmed | Correlation between cognitive impairment during the acute phase of first cerebral infarction and development of long-term pseudobulbar affect |
title_short | Correlation between cognitive impairment during the acute phase of first cerebral infarction and development of long-term pseudobulbar affect |
title_sort | correlation between cognitive impairment during the acute phase of first cerebral infarction and development of long-term pseudobulbar affect |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880411/ https://www.ncbi.nlm.nih.gov/pubmed/29636612 http://dx.doi.org/10.2147/NDT.S161792 |
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