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The importance of imaging strategies for pre-clinical and clinical in vivo distribution of oncolytic viruses
Oncolytic viruses (OVs) are an emergent and unique therapy for cancer patients. Similar to chemo- and radiation therapy, OV can lyse (kill) cancer cell directly. In general, the advantages of OVs over other treatments are primarily: a higher safety profile (as shown by less adverse effects), ability...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880516/ https://www.ncbi.nlm.nih.gov/pubmed/29637059 http://dx.doi.org/10.2147/OV.S137159 |
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author | Pelin, Adrian Wang, Jiahu Bell, John Le Boeuf, Fabrice |
author_facet | Pelin, Adrian Wang, Jiahu Bell, John Le Boeuf, Fabrice |
author_sort | Pelin, Adrian |
collection | PubMed |
description | Oncolytic viruses (OVs) are an emergent and unique therapy for cancer patients. Similar to chemo- and radiation therapy, OV can lyse (kill) cancer cell directly. In general, the advantages of OVs over other treatments are primarily: a higher safety profile (as shown by less adverse effects), ability to replicate, transgene(s) delivery, and stimulation of a host’s immune system against cancer. The latter has prompted successful use of OVs with other immunotherapeutic strategies in a synergistic manner. In spite of extended testing in pre-clinical and clinical setting, using biologically derived therapeutics like virus always raises potential concerns about safety (replication at non-intended locations) and bio-availability of the product. Recent advent in in vivo imaging techniques dramatically improves the convenience of use, quality of pictures, and amount of information acquired. Easy assessing of safety/localization of the biotherapeutics like OVs became a new potential weapon in the physician’s arsenal to improve treatment outcome. Given that OVs are typically replicating, in vivo imaging can also track virus replication and persistence as well as precisely mapping tumor tissues presence. This review discusses the importance of imaging in vivo in evaluating OV efficacy, as well as currently available tools and techniques. |
format | Online Article Text |
id | pubmed-5880516 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-58805162018-04-10 The importance of imaging strategies for pre-clinical and clinical in vivo distribution of oncolytic viruses Pelin, Adrian Wang, Jiahu Bell, John Le Boeuf, Fabrice Oncolytic Virother Review Oncolytic viruses (OVs) are an emergent and unique therapy for cancer patients. Similar to chemo- and radiation therapy, OV can lyse (kill) cancer cell directly. In general, the advantages of OVs over other treatments are primarily: a higher safety profile (as shown by less adverse effects), ability to replicate, transgene(s) delivery, and stimulation of a host’s immune system against cancer. The latter has prompted successful use of OVs with other immunotherapeutic strategies in a synergistic manner. In spite of extended testing in pre-clinical and clinical setting, using biologically derived therapeutics like virus always raises potential concerns about safety (replication at non-intended locations) and bio-availability of the product. Recent advent in in vivo imaging techniques dramatically improves the convenience of use, quality of pictures, and amount of information acquired. Easy assessing of safety/localization of the biotherapeutics like OVs became a new potential weapon in the physician’s arsenal to improve treatment outcome. Given that OVs are typically replicating, in vivo imaging can also track virus replication and persistence as well as precisely mapping tumor tissues presence. This review discusses the importance of imaging in vivo in evaluating OV efficacy, as well as currently available tools and techniques. Dove Medical Press 2018-03-28 /pmc/articles/PMC5880516/ /pubmed/29637059 http://dx.doi.org/10.2147/OV.S137159 Text en © 2018 Pelin et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Pelin, Adrian Wang, Jiahu Bell, John Le Boeuf, Fabrice The importance of imaging strategies for pre-clinical and clinical in vivo distribution of oncolytic viruses |
title | The importance of imaging strategies for pre-clinical and clinical in vivo distribution of oncolytic viruses |
title_full | The importance of imaging strategies for pre-clinical and clinical in vivo distribution of oncolytic viruses |
title_fullStr | The importance of imaging strategies for pre-clinical and clinical in vivo distribution of oncolytic viruses |
title_full_unstemmed | The importance of imaging strategies for pre-clinical and clinical in vivo distribution of oncolytic viruses |
title_short | The importance of imaging strategies for pre-clinical and clinical in vivo distribution of oncolytic viruses |
title_sort | importance of imaging strategies for pre-clinical and clinical in vivo distribution of oncolytic viruses |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880516/ https://www.ncbi.nlm.nih.gov/pubmed/29637059 http://dx.doi.org/10.2147/OV.S137159 |
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