Cargando…

Midlife insulin resistance, APOE genotype, and late-life brain amyloid accumulation

OBJECTIVE: To examine whether midlife insulin resistance is an independent risk factor for brain amyloid accumulation in vivo after 15 years, and whether this risk is modulated by APOE ε4 genotype. METHODS: This observational study examined 60 elderly volunteers without dementia (mean age at baselin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ekblad, Laura L., Johansson, Jarkko, Helin, Semi, Viitanen, Matti, Laine, Hanna, Puukka, Pauli, Jula, Antti, Rinne, Juha O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880630/ https://www.ncbi.nlm.nih.gov/pubmed/29476033 http://dx.doi.org/10.1212/WNL.0000000000005214

Ejemplares similares

Midlife Insulin Resistance as a Predictor for Late-Life Cognitive Function and Cerebrovascular Lesions
por: Toppala, Sini, et al.
Publicado: (2019)

Association of Early β-Amyloid Accumulation and Neuroinflammation Measured With [(11)C]PBR28 in Elderly Individuals Without Dementia
por: Toppala, Sini, et al.
Publicado: (2021)

Association of Midlife Inflammatory Markers With Cognitive Performance at 10-Year Follow-up
por: Kipinoinen, Teemu, et al.
Publicado: (2022)

Oral Glucose Tolerance Test Predicts Episodic Memory Decline: A 10-Year Population-Based Follow-up Study
por: Toppala, Sini, et al.
Publicado: (2021)

Impaired Early Insulin Response to Glucose Load Predicts Episodic Memory Decline: A 10-Year Population-Based Cohort Follow-Up of 45–74-Year-Old Men and Women
por: Toppala, Sini, et al.
Publicado: (2023)

APOE ε4 gene dose effect on imaging and blood biomarkers of neuroinflammation and beta-amyloid in cognitively unimpaired elderly
por: Snellman, Anniina, et al.
Publicado: (2023)

Insulin resistance and body mass index are associated with TSPO PET in cognitively unimpaired elderly
por: Ekblad, Laura L, et al.
Publicado: (2023)

Increased dopamine release after working-memory updating training: Neurochemical correlates of transfer
por: Bäckman, Lars, et al.
Publicado: (2017)

Effect of APOE ε4 genotype on amyloid-β and tau accumulation in Alzheimer’s disease
por: Baek, Min Seok, et al.
Publicado: (2020)

Sex and APOE: A memory advantage in male APOE ε4 carriers in midlife
por: Zokaei, Nahid, et al.
Publicado: (2017)

Change in brain amyloid load and cognition in patients with amnestic mild cognitive impairment: a 3-year follow-up study
por: Rauhala, Elina, et al.
Publicado: (2022)

Body Composition in Late Midlife as a Predictor of Accelerated Age-associated Deficit-accumulation From Late Midlife into Old Age: A Longitudinal Birth Cohort Study
por: Haapanen, Markus J, et al.
Publicado: (2022)

Association of neuroinflammation with episodic memory: a [(11)C]PBR28 PET study in cognitively discordant twin pairs
por: Lindgren, Noora, et al.
Publicado: (2020)

Adenosine A(2A) receptor availability in patients with early- and moderate-stage Parkinson’s disease
por: Waggan, Imran, et al.
Publicado: (2022)

Disentangling the Role of Working Memory in Parkinson’s Disease
por: Salmi, Juha, et al.
Publicado: (2020)

Differential association of cerebral blood flow and anisocytosis in APOE ε4 carriers at midlife
por: Dounavi, Maria-Eleni, et al.
Publicado: (2023)

Brain Glucose Metabolism in Health, Obesity, and Cognitive Decline—Does Insulin Have Anything to Do with It? A Narrative Review
por: Rebelos, Eleni, et al.
Publicado: (2021)

Direct Comparison of [(18)F]F-DPA with [(18)F]DPA-714 and [(11)C]PBR28 for Neuroinflammation Imaging in the same Alzheimer’s Disease Model Mice and Healthy Controls
por: López-Picón, Francisco R., et al.
Publicado: (2021)

Brain ApoA-I, ApoJ and ApoE Immunodetection in Cerebral Amyloid Angiopathy
por: Camacho, Jessica, et al.
Publicado: (2019)

Midlife Lifestyle Activities Moderate APOE ε4 Effect on in vivo Alzheimer’s Disease Pathologies
por: Jeon, So Yeon, et al.
Publicado: (2020)

APOE-amyloid interaction: Therapeutic targets
por: Wisniewski, Thomas, et al.
Publicado: (2020)

Is ApoE ɛ 4 a good biomarker for amyloid pathology in late onset Alzheimer’s disease?
por: Ba, Maowen, et al.
Publicado: (2016)

Is late-onset Alzheimer's disease really a disease of midlife?
por: Ritchie, Karen, et al.
Publicado: (2015)

Midlife work-related stress is associated with late-life cognition
por: Sindi, Shireen, et al.
Publicado: (2017)

ASIC-E4: Interplay of Beta-Amyloid, Synaptic Density and Neuroinflammation in Cognitively Normal Volunteers With Three Levels of Genetic Risk for Late-Onset Alzheimer's Disease – Study Protocol and Baseline Characteristics
por: Snellman, Anniina, et al.
Publicado: (2022)

Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis
por: Kim, Jungsu, et al.
Publicado: (2012)

Regional gray matter correlates of memory for emotion-laden words in middle-aged and older adults: A voxel-based morphometry study
por: Saarela, Carina, et al.
Publicado: (2017)

Effect of polycystic ovary syndrome on cardiac autonomic function at a late fertile age: a prospective Northern Finland Birth Cohort 1966 study
por: Ollila, Meri-Maija, et al.
Publicado: (2019)

EARLY-LIFE SOCIOECONOMIC POSITION AND ACCUMULATION OF HEALTH-RELATED DEFICITS IN MIDLIFE
por: Rogers, Nina, et al.
Publicado: (2019)

Associations of Midlife and Late-Life Blood Pressure Status With Late-Life Retinal OCT Measures
por: Pan-Doh, Nathan, et al.
Publicado: (2023)

The Association of Body Size, Shape and Composition with Vertebral Size in Midlife – The Northern Finland Birth Cohort 1966 Study
por: Oura, Petteri, et al.
Publicado: (2019)

Midlife Healthy-Diet Index and Late-Life Dementia and Alzheimer's Disease
por: Eskelinen, Marjo H., et al.
Publicado: (2011)

Body mass index across midlife and cognitive change in late life
por: Dahl, Anna K., et al.
Publicado: (2012)

Midlife managerial experience is linked to late life hippocampal morphology and function
por: Suo, C., et al.
Publicado: (2016)

Cognitive efficiency in late midlife is linked to lifestyle characteristics and allostatic load
por: Narbutas, Justinas, et al.
Publicado: (2019)

Incident prolonged QT interval in midlife and late-life cognitive performance
por: Suemoto, Claudia K., et al.
Publicado: (2020)

Lipid Profiles and APOE4 Allele Impact Midlife Cognitive Decline in HIV-Infected Men on Antiretroviral Therapy
por: Mukerji, Shibani S., et al.
Publicado: (2016)

Family history and APOE4 risk for Alzheimer's disease impact the neural correlates of episodic memory by early midlife
por: Rajah, M.N., et al.
Publicado: (2017)

Women’s Midlife Health: Why the Midlife Matters
por: Harlow, Siobán D., et al.
Publicado: (2015)

High-impact exercise in adulthood and vertebral dimensions in midlife - the Northern Finland Birth Cohort 1966 study
por: Oura, Petteri, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_g8imu1c8hkrli9jbm1kqm77e5e