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A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel

Piezo1 represents a prototype of eukaryotic mechanotransduction channels. The full-length 2547-residue mouse Piezo1 possesses a unique 38-transmembrane-helix (TM) topology and is organized into a three-bladed, propeller-shaped architecture, comprising a central ion-conducting pore, three peripheral...

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Detalles Bibliográficos
Autores principales:	Wang, Yanfeng, Chi, Shaopeng, Guo, Huifang, Li, Guang, Wang, Li, Zhao, Qiancheng, Rao, Yu, Zu, Liansuo, He, Wei, Xiao, Bailong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880808/ https://www.ncbi.nlm.nih.gov/pubmed/29610524 http://dx.doi.org/10.1038/s41467-018-03570-9

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