Selective deletion of PPARβ/δ in fibroblasts causes dermal fibrosis by attenuated LRG1 expression

Connective tissue diseases of the skin are characterized by excessive collagen deposition in the skin and internal organs. Fibroblasts play a pivotal role in the clinical presentation of these conditions. Nuclear receptor peroxisome-proliferator activated receptors (PPARs) are therapeutic targets fo...

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Detalles Bibliográficos
Autores principales: Sng, Ming Keat, Chan, Jeremy Soon Kiat, Teo, Ziqiang, Phua, Terri, Tan, Eddie Han Pin, Wee, Jonathan Wei Kiat, Koh, Nikki Jun Ning, Tan, Chek Kun, Chen, Jia Peng, Pal, Mintu, Tong, Benny Meng Kiat, Tnay, Ya Lin, Ng, Xuan Rui, Zhu, Pengcheng, Chiba, Shunsuke, Wang, Xiaomeng, Wahli, Walter, Tan, Nguan Soon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880809/
https://www.ncbi.nlm.nih.gov/pubmed/29619245
http://dx.doi.org/10.1038/s41421-018-0014-5

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