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Exploring Linkages between Taxonomic and Functional Profiles of the Human Microbiome
Microbiome studies typically focus on characterizing the taxonomic and functional profiles of the microbes within a community. Functional profiling is generally thought to be superior to taxonomic profiling for investigating human-microbe interactions, but there are several limitations and challenge...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Society for Microbiology
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881027/ https://www.ncbi.nlm.nih.gov/pubmed/29629420 http://dx.doi.org/10.1128/mSystems.00163-17 |
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author | Langille, Morgan G. I. |
author_facet | Langille, Morgan G. I. |
author_sort | Langille, Morgan G. I. |
collection | PubMed |
description | Microbiome studies typically focus on characterizing the taxonomic and functional profiles of the microbes within a community. Functional profiling is generally thought to be superior to taxonomic profiling for investigating human-microbe interactions, but there are several limitations and challenges to existing approaches. This Perspective discusses the current sequencing and bioinformatic methods for producing taxonomic and functional profiles, recent studies utilizing and comparing these technologies, and the existing challenges and limitations of these data. In addition, functional versus taxonomic conservation across the population is questioned, while future research that focuses on investigating the taxonomic diversity of microbial functions is proposed. |
format | Online Article Text |
id | pubmed-5881027 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | American Society for Microbiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-58810272018-04-06 Exploring Linkages between Taxonomic and Functional Profiles of the Human Microbiome Langille, Morgan G. I. mSystems Perspective Microbiome studies typically focus on characterizing the taxonomic and functional profiles of the microbes within a community. Functional profiling is generally thought to be superior to taxonomic profiling for investigating human-microbe interactions, but there are several limitations and challenges to existing approaches. This Perspective discusses the current sequencing and bioinformatic methods for producing taxonomic and functional profiles, recent studies utilizing and comparing these technologies, and the existing challenges and limitations of these data. In addition, functional versus taxonomic conservation across the population is questioned, while future research that focuses on investigating the taxonomic diversity of microbial functions is proposed. American Society for Microbiology 2018-03-27 /pmc/articles/PMC5881027/ /pubmed/29629420 http://dx.doi.org/10.1128/mSystems.00163-17 Text en Copyright © 2018 Langille. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Perspective Langille, Morgan G. I. Exploring Linkages between Taxonomic and Functional Profiles of the Human Microbiome |
title | Exploring Linkages between Taxonomic and Functional Profiles of the Human Microbiome |
title_full | Exploring Linkages between Taxonomic and Functional Profiles of the Human Microbiome |
title_fullStr | Exploring Linkages between Taxonomic and Functional Profiles of the Human Microbiome |
title_full_unstemmed | Exploring Linkages between Taxonomic and Functional Profiles of the Human Microbiome |
title_short | Exploring Linkages between Taxonomic and Functional Profiles of the Human Microbiome |
title_sort | exploring linkages between taxonomic and functional profiles of the human microbiome |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881027/ https://www.ncbi.nlm.nih.gov/pubmed/29629420 http://dx.doi.org/10.1128/mSystems.00163-17 |
work_keys_str_mv | AT langillemorgangi exploringlinkagesbetweentaxonomicandfunctionalprofilesofthehumanmicrobiome |