Derivation of a disease-specific human induced pluripotent stem cell line from a biliary atresia patient

Biliary atresia (BA) is a common cause of pediatric end-stage liver disease. While its etiology is not yet clear, evidence has suggested that BA results from interactions between genetic susceptibility and environmental factors. Disease relevant human cellular models of BA will facilitate identifica...

Descripción completa

Detalles Bibliográficos
Autores principales: Tian, Lipeng, Eldridge, Lindsey, Chaudhari, Pooja, Zhang, Linyi, Anders, Robert A., Schwarz, Kathleen B., Ye, Zhaohui, Jang, Yoon-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881114/
https://www.ncbi.nlm.nih.gov/pubmed/29034890
http://dx.doi.org/10.1016/j.scr.2017.08.001
_version_ 1783311259011121152
author Tian, Lipeng
Eldridge, Lindsey
Chaudhari, Pooja
Zhang, Linyi
Anders, Robert A.
Schwarz, Kathleen B.
Ye, Zhaohui
Jang, Yoon-Young
author_facet Tian, Lipeng
Eldridge, Lindsey
Chaudhari, Pooja
Zhang, Linyi
Anders, Robert A.
Schwarz, Kathleen B.
Ye, Zhaohui
Jang, Yoon-Young
author_sort Tian, Lipeng
collection PubMed
description Biliary atresia (BA) is a common cause of pediatric end-stage liver disease. While its etiology is not yet clear, evidence has suggested that BA results from interactions between genetic susceptibility and environmental factors. Disease relevant human cellular models of BA will facilitate identification of both genetic and environmental factors that are important for disease prevention and treatment. Here we report the generation of a human induced pluripotent stem cell line from a BA patient using episomal vectors. Patient-specific BA iPSC lines provide valuable tools for disease mechanism study and drug development.
format Online
Article
Text
id pubmed-5881114
institution National Center for Biotechnology Information
language English
publishDate 2017
record_format MEDLINE/PubMed
spelling pubmed-58811142018-04-03 Derivation of a disease-specific human induced pluripotent stem cell line from a biliary atresia patient Tian, Lipeng Eldridge, Lindsey Chaudhari, Pooja Zhang, Linyi Anders, Robert A. Schwarz, Kathleen B. Ye, Zhaohui Jang, Yoon-Young Stem Cell Res Article Biliary atresia (BA) is a common cause of pediatric end-stage liver disease. While its etiology is not yet clear, evidence has suggested that BA results from interactions between genetic susceptibility and environmental factors. Disease relevant human cellular models of BA will facilitate identification of both genetic and environmental factors that are important for disease prevention and treatment. Here we report the generation of a human induced pluripotent stem cell line from a BA patient using episomal vectors. Patient-specific BA iPSC lines provide valuable tools for disease mechanism study and drug development. 2017-08-08 2017-10 /pmc/articles/PMC5881114/ /pubmed/29034890 http://dx.doi.org/10.1016/j.scr.2017.08.001 Text en This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Tian, Lipeng
Eldridge, Lindsey
Chaudhari, Pooja
Zhang, Linyi
Anders, Robert A.
Schwarz, Kathleen B.
Ye, Zhaohui
Jang, Yoon-Young
Derivation of a disease-specific human induced pluripotent stem cell line from a biliary atresia patient
title Derivation of a disease-specific human induced pluripotent stem cell line from a biliary atresia patient
title_full Derivation of a disease-specific human induced pluripotent stem cell line from a biliary atresia patient
title_fullStr Derivation of a disease-specific human induced pluripotent stem cell line from a biliary atresia patient
title_full_unstemmed Derivation of a disease-specific human induced pluripotent stem cell line from a biliary atresia patient
title_short Derivation of a disease-specific human induced pluripotent stem cell line from a biliary atresia patient
title_sort derivation of a disease-specific human induced pluripotent stem cell line from a biliary atresia patient
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881114/
https://www.ncbi.nlm.nih.gov/pubmed/29034890
http://dx.doi.org/10.1016/j.scr.2017.08.001
work_keys_str_mv AT tianlipeng derivationofadiseasespecifichumaninducedpluripotentstemcelllinefromabiliaryatresiapatient
AT eldridgelindsey derivationofadiseasespecifichumaninducedpluripotentstemcelllinefromabiliaryatresiapatient
AT chaudharipooja derivationofadiseasespecifichumaninducedpluripotentstemcelllinefromabiliaryatresiapatient
AT zhanglinyi derivationofadiseasespecifichumaninducedpluripotentstemcelllinefromabiliaryatresiapatient
AT andersroberta derivationofadiseasespecifichumaninducedpluripotentstemcelllinefromabiliaryatresiapatient
AT schwarzkathleenb derivationofadiseasespecifichumaninducedpluripotentstemcelllinefromabiliaryatresiapatient
AT yezhaohui derivationofadiseasespecifichumaninducedpluripotentstemcelllinefromabiliaryatresiapatient
AT jangyoonyoung derivationofadiseasespecifichumaninducedpluripotentstemcelllinefromabiliaryatresiapatient

Ejemplares similares