Cargando…

Halofuginone Attenuates Osteoarthritis by Rescuing Bone Remodeling in Subchondral Bone Through Oral Gavage

Osteoarthritis (OA) is a common debilitating joint disorder worldwide without effective medical therapy. Articular cartilage and subchondral bone act in concert as a functional unit with the onset of OA. Halofuginone is an analog of the alkaloid febrifugine extracted from the plant Dichroa febrifuga...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mu, Wenbo, Xu, Boyong, Ma, Hairong, Li, Jiao, Ji, Baochao, Zhang, Zhendong, Amat, Abdusami, Cao, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881118/ https://www.ncbi.nlm.nih.gov/pubmed/29636687 http://dx.doi.org/10.3389/fphar.2018.00269

Ejemplares similares

Isoliquiritigenin blunts osteoarthritis by inhibition of bone resorption and angiogenesis in subchondral bone
por: Ji, Baochao, et al.
Publicado: (2018)

Artesunate, an Anti-Malaria Agent, Attenuates Experimental Osteoarthritis by Inhibiting Bone Resorption and CD31(hi)Emcn(hi) Vessel Formation in Subchondral Bone
por: Li, Yicheng, et al.
Publicado: (2019)

Isoliquiritigenin suppresses IL-1β induced apoptosis and inflammation in chondrocyte-like ATDC5 cells by inhibiting NF-κB and exerts chondroprotective effects on a mouse model of anterior cruciate ligament transection
por: Ji, Baochao, et al.
Publicado: (2017)

Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone
por: Cui, Zhuang, et al.
Publicado: (2016)

Subchondral bone remodelling and osteoarthritis
por: Román-Blas, Jorge A, et al.
Publicado: (2012)

Subchondral bone remodelling in osteoarthritis
por: Donell, Simon
Publicado: (2019)

Parathyroid hormone attenuates osteoarthritis pain by remodeling subchondral bone in mice
por: Sun, Qi, et al.
Publicado: (2021)

Dihydroartemisinin attenuates osteoarthritis by inhibiting abnormal bone remodeling and angiogenesis in subchondral bone
por: Ma, Long, et al.
Publicado: (2021)

Inhibition of cyclooxygenase-2 activity in subchondral bone modifies a subtype of osteoarthritis
por: Tu, Manli, et al.
Publicado: (2019)

Subchondral Bone Remodeling: A Therapeutic Target for Osteoarthritis
por: Zhu, Xiaobo, et al.
Publicado: (2021)

Inhibition of PGE2 in Subchondral Bone Attenuates Osteoarthritis
por: Sun, Qi, et al.
Publicado: (2022)

Autophagy attenuates osteoarthritis in mice by inhibiting chondrocyte pyroptosis and improving subchondral bone remodeling
por: Yan, Jiangbo, et al.
Publicado: (2023)

Osteoclasts secrete leukemia inhibitory factor to promote abnormal bone remodeling of subchondral bone in osteoarthritis
por: Zhao, Xin, et al.
Publicado: (2022)

Estrogen Modulates Cartilage and Subchondral Bone Remodeling in an Ovariectomized Rat Model of Postmenopausal Osteoarthritis
por: Xu, Xiao, et al.
Publicado: (2019)

Subchondral bone architecture and quality in osteoarthritis
por: Aspden, RM
Publicado: (2004)

Targeting subchondral bone in osteoporotic osteoarthritis
por: Roman-Blas, Jorge A, et al.
Publicado: (2014)

The Importance of Subchondral Bone in the Pathophysiology of Osteoarthritis
por: Stewart, Holly L., et al.
Publicado: (2018)

Subchondral bone histology and grading in osteoarthritis
por: Aho, Olli-Matti, et al.
Publicado: (2017)

Subchondral bone microenvironment in osteoarthritis and pain
por: Hu, Yan, et al.
Publicado: (2021)

Betaine Attenuates Osteoarthritis by Inhibiting Osteoclastogenesis and Angiogenesis in Subchondral Bone
por: Yajun, Wang, et al.
Publicado: (2021)

Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis
por: Bellido, Miriam, et al.
Publicado: (2010)

Calcium-phosphate complex increased during subchondral bone remodeling affects earlystage osteoarthritis
por: Jung, Youn-Kwan, et al.
Publicado: (2018)

Microstructural analysis of subchondral bone in knee osteoarthritis
por: Holzer, L.A., et al.
Publicado: (2020)

Epigenetic Regulation of Chondrocytes and Subchondral Bone in Osteoarthritis
por: Ball, Hope C., et al.
Publicado: (2022)

Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression
por: Zhang, Hao, et al.
Publicado: (2023)

Jintiange Capsules Ameliorate Osteoarthritis by Modulating Subchondral Bone Remodeling and Protecting Cartilage Against Degradation
por: Zhuang, Chenyang, et al.
Publicado: (2021)

Expansion of myeloid-derived suppressor cells contributes to metabolic osteoarthritis through subchondral bone remodeling
por: Zhang, Lixia, et al.
Publicado: (2021)

Genome-wide expression profiles of subchondral bone in osteoarthritis
por: Chou, Ching-Heng, et al.
Publicado: (2013)

Sclerostin expression in the subchondral bone of patients with knee osteoarthritis
por: Wu, Long, et al.
Publicado: (2016)

Subchondral bone proteomics in osteoarthritis: Current status and perspectives
por: Boris Chan, Pok Man, et al.
Publicado: (2015)

Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis
por: Hu, Wenhui, et al.
Publicado: (2021)

The role of cells and signal pathways in subchondral bone in osteoarthritis
por: Luo, Pan, et al.
Publicado: (2023)

Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes
por: Li, Guangyi, et al.
Publicado: (2013)

Subchondral Bone Plate Changes More Rapidly than Trabecular Bone in Osteoarthritis
por: Zamli, Zaitunnatakhin, et al.
Publicado: (2016)

Noncoding RNAs in subchondral bone osteoclast function and their therapeutic potential for osteoarthritis
por: Duan, Li, et al.
Publicado: (2020)

Peripheral nerves in the tibial subchondral bone: the role of pain and homeostasis in osteoarthritis
por: Sun, Qi, et al.
Publicado: (2022)

Cross-talk between subchondral bone and articular cartilage in osteoarthritis
por: Goldring, Steven R
Publicado: (2012)

Interplay between Cartilage and Subchondral Bone Contributing to Pathogenesis of Osteoarthritis
por: Sharma, Ashish R., et al.
Publicado: (2013)

Association between subchondral bone structure and osteoarthritis histopathological grade
por: Finnilä, Mikko A. J., et al.
Publicado: (2016)

Hemodynamic stress shapes subchondral bone in osteoarthritis: An emerging hypothesis
por: Ni, Ruiyan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_jbqcvdonihpnr18m58j2au0d5d