Organic mononitrites of 1,2-propanediol act as an effective NO-releasing vasodilator in pulmonary hypertension and exhibit no cross-tolerance with nitroglycerin in anesthetized pigs

PURPOSE: Clinically available intravenous (IV) nitric oxide (NO) donor drugs such as nitroglycerin (GTN) cause systemic hypotension and/or tolerance development. In a porcine model, novel NO donor compounds – the organic mononitrites of 1,2-propanediol (PDNO) – were compared to GTN with regard to pu...

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Detalles Bibliográficos
Autores principales: Nilsson, Kristofer F, Goździk, Waldemar, Frostell, Claes, Zieliński, Stanisław, Zielińska, Marzena, Ratajczak, Kornel, Skrzypczak, Piotr, Rodziewicz, Sylwia, Albert, Johanna, Gustafsson, Lars E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881281/
https://www.ncbi.nlm.nih.gov/pubmed/29636602
http://dx.doi.org/10.2147/DDDT.S149727

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