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Homocysteine causes dysfunction of chondrocytes and oxidative stress through repression of SIRT1/AMPK pathway: A possible link between hyperhomocysteinemia and osteoarthritis

Emerging evidence has indicated that the perturbed expression of homocysteine (Hcy) may induce mitochondrial dysfunction and disturb bone metabolism. Sirtuin 1 (SIRT1) and AMP-activated protein kinase (AMPK) are two critical sensors that regulate mitochondrial biogenesis and have been recognized as...

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Detalles Bibliográficos
Autores principales:	Ma, Ching-Hou, Chiua,, Yen Chun, Wu, Chin-Hsien, Jou, I.-Ming, Tu, Yuan-Kun, Hung, Ching-Hsia, Hsieh, Pei-Ling, Tsai, Kun-Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881416/ https://www.ncbi.nlm.nih.gov/pubmed/29413962 http://dx.doi.org/10.1016/j.redox.2018.01.010

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