Dynamic rearrangement of the intrinsic ligand regulates KCNH potassium channels

KCNH voltage-gated potassium channels (EAG, ERG, and ELK) play significant roles in neuronal and cardiac excitability. They contain cyclic nucleotide-binding homology domains (CNBHDs) but are not directly regulated by cyclic nucleotides. Instead, the CNBHD ligand-binding cavity is occupied by an int...

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Detalles Bibliográficos
Autores principales: Dai, Gucan, James, Zachary M., Zagotta, William N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881448/
https://www.ncbi.nlm.nih.gov/pubmed/29567795
http://dx.doi.org/10.1085/jgp.201711989

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