4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses

Despite remarkable responses to cancer immunotherapy in a subset of patients, many patients remain resistant to these therapies. The tumor microenvironment can impose metabolic restrictions on T cell function, creating a resistance mechanism to immunotherapy. We have previously shown tumor-infiltrat...

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Detalles Bibliográficos
Autores principales: Menk, Ashley V., Scharping, Nicole E., Rivadeneira, Dayana B., Calderon, Michael J., Watson, McLane J., Dunstane, Deanna, Watkins, Simon C., Delgoffe, Greg M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881463/
https://www.ncbi.nlm.nih.gov/pubmed/29511066
http://dx.doi.org/10.1084/jem.20171068

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