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Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal

Here we describe a new mouse model that exploits the pattern of expression of the high-affinity IgG receptor (CD64) and allows diphtheria toxin (DT)–mediated ablation of tissue-resident macrophages and monocyte-derived cells. We found that the myeloid cells of the ear skin dermis are dominated by DT...

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Autores principales: Baranska, Anna, Shawket, Alaa, Jouve, Mabel, Baratin, Myriam, Malosse, Camille, Voluzan, Odessa, Vu Manh, Thien-Phong, Fiore, Frédéric, Bajénoff, Marc, Benaroch, Philippe, Dalod, Marc, Malissen, Marie, Henri, Sandrine, Malissen, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881467/
https://www.ncbi.nlm.nih.gov/pubmed/29511065
http://dx.doi.org/10.1084/jem.20171608
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author Baranska, Anna
Shawket, Alaa
Jouve, Mabel
Baratin, Myriam
Malosse, Camille
Voluzan, Odessa
Vu Manh, Thien-Phong
Fiore, Frédéric
Bajénoff, Marc
Benaroch, Philippe
Dalod, Marc
Malissen, Marie
Henri, Sandrine
Malissen, Bernard
author_facet Baranska, Anna
Shawket, Alaa
Jouve, Mabel
Baratin, Myriam
Malosse, Camille
Voluzan, Odessa
Vu Manh, Thien-Phong
Fiore, Frédéric
Bajénoff, Marc
Benaroch, Philippe
Dalod, Marc
Malissen, Marie
Henri, Sandrine
Malissen, Bernard
author_sort Baranska, Anna
collection PubMed
description Here we describe a new mouse model that exploits the pattern of expression of the high-affinity IgG receptor (CD64) and allows diphtheria toxin (DT)–mediated ablation of tissue-resident macrophages and monocyte-derived cells. We found that the myeloid cells of the ear skin dermis are dominated by DT-sensitive, melanin-laden cells that have been missed in previous studies and correspond to macrophages that have ingested melanosomes from neighboring melanocytes. Those cells have been referred to as melanophages in humans. We also identified melanophages in melanocytic melanoma. Benefiting of our knowledge on melanophage dynamics, we determined the identity, origin, and dynamics of the skin myeloid cells that capture and retain tattoo pigment particles. We showed that they are exclusively made of dermal macrophages. Using the possibility to delete them, we further demonstrated that tattoo pigment particles can undergo successive cycles of capture–release–recapture without any tattoo vanishing. Therefore, congruent with dermal macrophage dynamics, long-term tattoo persistence likely relies on macrophage renewal rather than on macrophage longevity.
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spelling pubmed-58814672018-10-02 Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal Baranska, Anna Shawket, Alaa Jouve, Mabel Baratin, Myriam Malosse, Camille Voluzan, Odessa Vu Manh, Thien-Phong Fiore, Frédéric Bajénoff, Marc Benaroch, Philippe Dalod, Marc Malissen, Marie Henri, Sandrine Malissen, Bernard J Exp Med Research Articles Here we describe a new mouse model that exploits the pattern of expression of the high-affinity IgG receptor (CD64) and allows diphtheria toxin (DT)–mediated ablation of tissue-resident macrophages and monocyte-derived cells. We found that the myeloid cells of the ear skin dermis are dominated by DT-sensitive, melanin-laden cells that have been missed in previous studies and correspond to macrophages that have ingested melanosomes from neighboring melanocytes. Those cells have been referred to as melanophages in humans. We also identified melanophages in melanocytic melanoma. Benefiting of our knowledge on melanophage dynamics, we determined the identity, origin, and dynamics of the skin myeloid cells that capture and retain tattoo pigment particles. We showed that they are exclusively made of dermal macrophages. Using the possibility to delete them, we further demonstrated that tattoo pigment particles can undergo successive cycles of capture–release–recapture without any tattoo vanishing. Therefore, congruent with dermal macrophage dynamics, long-term tattoo persistence likely relies on macrophage renewal rather than on macrophage longevity. Rockefeller University Press 2018-04-02 /pmc/articles/PMC5881467/ /pubmed/29511065 http://dx.doi.org/10.1084/jem.20171608 Text en © 2018 Baranska et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Research Articles
Baranska, Anna
Shawket, Alaa
Jouve, Mabel
Baratin, Myriam
Malosse, Camille
Voluzan, Odessa
Vu Manh, Thien-Phong
Fiore, Frédéric
Bajénoff, Marc
Benaroch, Philippe
Dalod, Marc
Malissen, Marie
Henri, Sandrine
Malissen, Bernard
Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal
title Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal
title_full Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal
title_fullStr Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal
title_full_unstemmed Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal
title_short Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal
title_sort unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881467/
https://www.ncbi.nlm.nih.gov/pubmed/29511065
http://dx.doi.org/10.1084/jem.20171608
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