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Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal
Here we describe a new mouse model that exploits the pattern of expression of the high-affinity IgG receptor (CD64) and allows diphtheria toxin (DT)–mediated ablation of tissue-resident macrophages and monocyte-derived cells. We found that the myeloid cells of the ear skin dermis are dominated by DT...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881467/ https://www.ncbi.nlm.nih.gov/pubmed/29511065 http://dx.doi.org/10.1084/jem.20171608 |
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author | Baranska, Anna Shawket, Alaa Jouve, Mabel Baratin, Myriam Malosse, Camille Voluzan, Odessa Vu Manh, Thien-Phong Fiore, Frédéric Bajénoff, Marc Benaroch, Philippe Dalod, Marc Malissen, Marie Henri, Sandrine Malissen, Bernard |
author_facet | Baranska, Anna Shawket, Alaa Jouve, Mabel Baratin, Myriam Malosse, Camille Voluzan, Odessa Vu Manh, Thien-Phong Fiore, Frédéric Bajénoff, Marc Benaroch, Philippe Dalod, Marc Malissen, Marie Henri, Sandrine Malissen, Bernard |
author_sort | Baranska, Anna |
collection | PubMed |
description | Here we describe a new mouse model that exploits the pattern of expression of the high-affinity IgG receptor (CD64) and allows diphtheria toxin (DT)–mediated ablation of tissue-resident macrophages and monocyte-derived cells. We found that the myeloid cells of the ear skin dermis are dominated by DT-sensitive, melanin-laden cells that have been missed in previous studies and correspond to macrophages that have ingested melanosomes from neighboring melanocytes. Those cells have been referred to as melanophages in humans. We also identified melanophages in melanocytic melanoma. Benefiting of our knowledge on melanophage dynamics, we determined the identity, origin, and dynamics of the skin myeloid cells that capture and retain tattoo pigment particles. We showed that they are exclusively made of dermal macrophages. Using the possibility to delete them, we further demonstrated that tattoo pigment particles can undergo successive cycles of capture–release–recapture without any tattoo vanishing. Therefore, congruent with dermal macrophage dynamics, long-term tattoo persistence likely relies on macrophage renewal rather than on macrophage longevity. |
format | Online Article Text |
id | pubmed-5881467 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-58814672018-10-02 Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal Baranska, Anna Shawket, Alaa Jouve, Mabel Baratin, Myriam Malosse, Camille Voluzan, Odessa Vu Manh, Thien-Phong Fiore, Frédéric Bajénoff, Marc Benaroch, Philippe Dalod, Marc Malissen, Marie Henri, Sandrine Malissen, Bernard J Exp Med Research Articles Here we describe a new mouse model that exploits the pattern of expression of the high-affinity IgG receptor (CD64) and allows diphtheria toxin (DT)–mediated ablation of tissue-resident macrophages and monocyte-derived cells. We found that the myeloid cells of the ear skin dermis are dominated by DT-sensitive, melanin-laden cells that have been missed in previous studies and correspond to macrophages that have ingested melanosomes from neighboring melanocytes. Those cells have been referred to as melanophages in humans. We also identified melanophages in melanocytic melanoma. Benefiting of our knowledge on melanophage dynamics, we determined the identity, origin, and dynamics of the skin myeloid cells that capture and retain tattoo pigment particles. We showed that they are exclusively made of dermal macrophages. Using the possibility to delete them, we further demonstrated that tattoo pigment particles can undergo successive cycles of capture–release–recapture without any tattoo vanishing. Therefore, congruent with dermal macrophage dynamics, long-term tattoo persistence likely relies on macrophage renewal rather than on macrophage longevity. Rockefeller University Press 2018-04-02 /pmc/articles/PMC5881467/ /pubmed/29511065 http://dx.doi.org/10.1084/jem.20171608 Text en © 2018 Baranska et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Research Articles Baranska, Anna Shawket, Alaa Jouve, Mabel Baratin, Myriam Malosse, Camille Voluzan, Odessa Vu Manh, Thien-Phong Fiore, Frédéric Bajénoff, Marc Benaroch, Philippe Dalod, Marc Malissen, Marie Henri, Sandrine Malissen, Bernard Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal |
title | Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal |
title_full | Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal |
title_fullStr | Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal |
title_full_unstemmed | Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal |
title_short | Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal |
title_sort | unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881467/ https://www.ncbi.nlm.nih.gov/pubmed/29511065 http://dx.doi.org/10.1084/jem.20171608 |
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