Cargando…

ADAM17 is required for EGF-R–induced intestinal tumors via IL-6 trans-signaling

Colorectal cancer is treated with antibodies blocking epidermal growth factor receptor (EGF-R), but therapeutic success is limited. EGF-R is stimulated by soluble ligands, which are derived from transmembrane precursors by ADAM17-mediated proteolytic cleavage. In mouse intestinal cancer models in th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schmidt, Stefanie, Schumacher, Neele, Schwarz, Jeanette, Tangermann, Simone, Kenner, Lukas, Schlederer, Michaela, Sibilia, Maria, Linder, Markus, Altendorf-Hofmann, Annelore, Knösel, Thomas, Gruber, Elisabeth S., Oberhuber, Georg, Bolik, Julia, Rehman, Ateequr, Sinha, Anupam, Lokau, Juliane, Arnold, Philipp, Cabron, Anne-Sophie, Zunke, Friederike, Becker-Pauly, Christoph, Preaudet, Adele, Nguyen, Paul, Huynh, Jennifer, Afshar-Sterle, Shoukat, Chand, Ashwini L., Westermann, Jürgen, Dempsey, Peter J., Garbers, Christoph, Schmidt-Arras, Dirk, Rosenstiel, Philip, Putoczki, Tracy, Ernst, Matthias, Rose-John, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881468/ https://www.ncbi.nlm.nih.gov/pubmed/29472497 http://dx.doi.org/10.1084/jem.20171696

Ejemplares similares

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
por: Ernst, Matthias, et al.
Publicado: (2015)

A single aromatic residue in sgp130Fc/olamkicept allows the discrimination between interleukin-6 and interleukin-11 trans-signaling
por: Lokau, Juliane, et al.
Publicado: (2021)

The enhanced susceptibility of ADAM-17 hypomorphic mice to DSS-induced colitis is not ameliorated by loss of RIPK3, revealing an unexpected function of ADAM-17 in necroptosis
por: Fuchslocher Chico, Johaiber, et al.
Publicado: (2018)

Generation of Soluble Interleukin-11 and Interleukin-6 Receptors: A Crucial Function for Proteases during Inflammation
por: Lokau, Juliane, et al.
Publicado: (2016)

The metalloprotease ADAM10 generates soluble interleukin-2 receptor alpha (sCD25) in vivo
por: Kirschke, Sophia, et al.
Publicado: (2022)

Confocal laser endomicroscopy to monitor the colonic mucosa of mice
por: Mielke, Lisa, et al.
Publicado: (2015)

Coding variants of the interleukin-11 receptor with reduced protein maturation show protease-dependent trans-signaling and transduce normal STAT3 signaling
por: Kespohl, Birte, et al.
Publicado: (2022)

ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation
por: Schumacher, Neele, et al.
Publicado: (2020)

Jak-Stat Signaling Induced by Interleukin-6 Family Cytokines in Hepatocellular Carcinoma
por: Lokau, Juliane, et al.
Publicado: (2019)

Distinct Expression Patterns of VEGFR 1-3 in Gastroenteropancreatic Neuroendocrine Neoplasms: Supporting Clinical Relevance, but not a Prognostic Factor
por: Bösch, Florian, et al.
Publicado: (2020)

Desmogleins as prognostic biomarkers in resected pancreatic ductal adenocarcinoma
por: Ormanns, Steffen, et al.
Publicado: (2015)

Immuno-histochemical correlation of fibrosis-related markers with the desmoplastic reaction of the mesentery in small intestine neuroendocrine neoplasms
por: Bösch, Florian, et al.
Publicado: (2022)

Expression Patterns of TOP2A and SIRT1 Are Predictive of Survival in Patients with High-Risk Soft Tissue Sarcomas Treated with a Neoadjuvant Anthracycline-Based Chemotherapy
por: Berclaz, Luc M., et al.
Publicado: (2021)

Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling
por: Arnold, Philipp, et al.
Publicado: (2017)

Interleukin-11 receptor expression on monocytes is dispensable for their recruitment and pathogen uptake during Leishmania major infection
por: Baars, Iris, et al.
Publicado: (2021)

TIM-3 Qualifies as a Potential Immunotherapeutic Target in Specific Subsets of Patients with High-Risk Soft Tissue Sarcomas (HR-STS)
por: Berclaz, Luc M., et al.
Publicado: (2023)

Functional Characterization of Colon Cancer-Associated Mutations in ADAM17: Modifications in the Pro-Domain Interfere with Trafficking and Maturation
por: Pavlenko, Egor, et al.
Publicado: (2019)

Functional Characterization of Colon-Cancer-Associated Variants in ADAM17 Affecting the Catalytic Domain
por: Dobert, Jan Philipp, et al.
Publicado: (2020)

Characterization of the Cancer-Associated Meprin Βeta Variants G45R and G89R
por: Gellrich, Antonin, et al.
Publicado: (2021)

Tocilizumab does not block interleukin-6 (IL-6) signaling in murine cells
por: Lokau, Juliane, et al.
Publicado: (2020)

Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells
por: Cabron, Anne-Sophie, et al.
Publicado: (2018)

Microbiomarkers in inflammatory bowel diseases: caveats come with caviar
por: Sommer, Felix, et al.
Publicado: (2017)

VISTA in Soft Tissue Sarcomas: A Perspective for Immunotherapy?
por: Albertsmeier, Markus, et al.
Publicado: (2022)

Activation of Toll-like Receptor 2 (TLR2) induces Interleukin-6 trans-signaling
por: Flynn, Charlotte M., et al.
Publicado: (2019)

Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP
por: Sammel, Martin, et al.
Publicado: (2019)

Joint Reconstituted Signaling of the IL-6 Receptor via Extracellular Vesicles
por: Arnold, Philipp, et al.
Publicado: (2020)

Cancer Testis Antigens and Immunotherapy: Expression of PRAME Is Associated with Prognosis in Soft Tissue Sarcoma
por: Albertsmeier, Markus, et al.
Publicado: (2020)

The Oncogene AF1Q is Associated with WNT and STAT Signaling and Offers a Novel Independent Prognostic Marker in Patients with Resectable Esophageal Cancer
por: Gruber, Elisabeth S., et al.
Publicado: (2019)

Erratum: Gruber, E.S.; et al. The Oncogene AF1Q is Associated with WNT and STAT Signaling and Offers a Novel Independent Prognostic Marker in Patients with Resectable Esophageal Cancer. Cells 2019, 8, 1357
por: Gruber, Elisabeth S., et al.
Publicado: (2020)

Anti–IL-6 cytokine treatment has no impact on elevated hematocrit or splenomegaly in a polycythemia vera mouse model
por: Baldauf, Conny K., et al.
Publicado: (2022)

Interleukin-6 controls recycling and degradation, but not internalization of its receptors
por: Flynn, Charlotte M., et al.
Publicado: (2021)

Tetraspanin 8 Subfamily Members Regulate Substrate-Specificity of a Disintegrin and Metalloprotease 17
por: Müller, Miryam, et al.
Publicado: (2022)

Impact of age on morbidity and outcome of concurrent radiochemotherapy in high-risk FIGO stage I to IVA carcinoma of the uterine cervix following laparoscopic surgery
por: Laurentius, Thea, et al.
Publicado: (2010)

Impact of metabolic indices of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography on post transplantation recurrence of hepatocellular carcinoma
por: Bauschke, Astrid, et al.
Publicado: (2022)

FOXM1: A novel drug target in gastroenteropancreatic neuroendocrine tumors
por: Briest, Franziska, et al.
Publicado: (2015)

The Implications of PDK1–4 on Tumor Energy Metabolism, Aggressiveness and Therapy Resistance
por: Atas, Emine, et al.
Publicado: (2020)

Early heme oxygenase 1 induction delays tumour initiation and enhances DNA damage repair in liver macrophages of Mdr2(−/−) mice
por: Barikbin, Roja, et al.
Publicado: (2018)

Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro
por: Flynn, Charlotte M., et al.
Publicado: (2020)

Impact of successful local ablative bridging therapy prior to liver transplantation on long-term survival in patients with hepatocellular carcinoma in cirrhosis
por: Bauschke, Astrid, et al.
Publicado: (2020)

A Biobank of Colorectal Cancer Patient-Derived Xenografts
por: Abdirahman, Suad M., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ui87h55nkk04k1kdvc2sqcsorh