CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss

Hearing loss caused by aging, noise, cisplatin toxicity, or other insults affects 360 million people worldwide, but there are no Food and Drug Administration–approved drugs to prevent or treat it. We screened 4,385 small molecules in a cochlear cell line and identified 10 compounds that protected ag...

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Detalles Bibliográficos
Autores principales: Teitz, Tal, Fang, Jie, Goktug, Asli N., Bonga, Justine D., Diao, Shiyong, Hazlitt, Robert A., Iconaru, Luigi, Morfouace, Marie, Currier, Duane, Zhou, Yinmei, Umans, Robyn A., Taylor, Michael R., Cheng, Cheng, Min, Jaeki, Freeman, Burgess, Peng, Junmin, Roussel, Martine F., Kriwacki, Richard, Guy, R. Kiplin, Chen, Taosheng, Zuo, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881471/
https://www.ncbi.nlm.nih.gov/pubmed/29514916
http://dx.doi.org/10.1084/jem.20172246

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