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Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection

Immune-Responsive Gene 1 (Irg1) is a mitochondrial enzyme that produces itaconate under inflammatory conditions, principally in cells of myeloid lineage. Cell culture studies suggest that itaconate regulates inflammation through its inhibitory effects on cytokine and reactive oxygen species producti...

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Detalles Bibliográficos
Autores principales:	Nair, Sharmila, Huynh, Jeremy P., Lampropoulou, Vicky, Loginicheva, Ekaterina, Esaulova, Ekaterina, Gounder, Anshu P., Boon, Adrianus C.M., Schwarzkopf, Elizabeth A., Bradstreet, Tara R., Edelson, Brian T., Artyomov, Maxim N., Stallings, Christina L., Diamond, Michael S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881474/ https://www.ncbi.nlm.nih.gov/pubmed/29511063 http://dx.doi.org/10.1084/jem.20180118

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