TAK1ng control: TAK1 restrains NLRP3 activation

In this issue of JEM, Malireddi et al. (https://doi.org/10.1084/jem.20171922) demonstrate that macrophage-specific loss of TAK1 causes spontaneous NLRP3 inflammasome activation, driven by unregulated TNF secretion and signaling. This has implications for therapeutically targeting TAK1, enhancing its...

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Detalles Bibliográficos
Autores principales: Mangan, Matthew Stephen, Latz, Eicke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
News
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881475/
https://www.ncbi.nlm.nih.gov/pubmed/29507056
http://dx.doi.org/10.1084/jem.20180282
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author Mangan, Matthew Stephen
Latz, Eicke
author_facet Mangan, Matthew Stephen
Latz, Eicke
author_sort Mangan, Matthew Stephen
collection PubMed
description In this issue of JEM, Malireddi et al. (https://doi.org/10.1084/jem.20171922) demonstrate that macrophage-specific loss of TAK1 causes spontaneous NLRP3 inflammasome activation, driven by unregulated TNF secretion and signaling. This has implications for therapeutically targeting TAK1, enhancing its potential function as an anticancer drug treatment.
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spelling pubmed-58814752018-10-02 TAK1ng control: TAK1 restrains NLRP3 activation Mangan, Matthew Stephen Latz, Eicke J Exp Med News In this issue of JEM, Malireddi et al. (https://doi.org/10.1084/jem.20171922) demonstrate that macrophage-specific loss of TAK1 causes spontaneous NLRP3 inflammasome activation, driven by unregulated TNF secretion and signaling. This has implications for therapeutically targeting TAK1, enhancing its potential function as an anticancer drug treatment. Rockefeller University Press 2018-04-02 /pmc/articles/PMC5881475/ /pubmed/29507056 http://dx.doi.org/10.1084/jem.20180282 Text en © 2018 Mangan and Latz http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle News
Mangan, Matthew Stephen
Latz, Eicke
TAK1ng control: TAK1 restrains NLRP3 activation
title TAK1ng control: TAK1 restrains NLRP3 activation
title_full TAK1ng control: TAK1 restrains NLRP3 activation
title_fullStr TAK1ng control: TAK1 restrains NLRP3 activation
title_full_unstemmed TAK1ng control: TAK1 restrains NLRP3 activation
title_short TAK1ng control: TAK1 restrains NLRP3 activation
title_sort tak1ng control: tak1 restrains nlrp3 activation
topic News
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881475/
https://www.ncbi.nlm.nih.gov/pubmed/29507056
http://dx.doi.org/10.1084/jem.20180282
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