MARCH1 protects the lipid raft and tetraspanin web from MHCII proteotoxicity in dendritic cells

Dendritic cells (DCs) produce major histocompatibility complex II (MHCII) in large amounts to function as professional antigen presenting cells. Paradoxically, DCs also ubiquitinate and degrade MHCII in a constitutive manner. Mice deficient in the MHCII-ubiquitinating enzyme membrane-anchored RING-C...

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Detalles Bibliográficos
Autores principales: Oh, Jaehak, Perry, Justin S.A., Pua, Heather, Irgens-Möller, Nicole, Ishido, Satoshi, Hsieh, Chyi-Song, Shin, Jeoung-Sook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881489/
https://www.ncbi.nlm.nih.gov/pubmed/29371232
http://dx.doi.org/10.1083/jcb.201611141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881489/
https://www.ncbi.nlm.nih.gov/pubmed/29371232
http://dx.doi.org/10.1083/jcb.201611141

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