Cargando…

IRE1–XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells

In mammalian pancreatic β cells, the IRE1α–XBP1 pathway is constitutively and highly activated under physiological conditions. To elucidate the precise role of this pathway, we constructed β cell–specific Ire1α conditional knockout (CKO) mice and established insulinoma cell lines in which Ire1α was...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tsuchiya, Yuichi, Saito, Michiko, Kadokura, Hiroshi, Miyazaki, Jun-ichi, Tashiro, Fumi, Imagawa, Yusuke, Iwawaki, Takao, Kohno, Kenji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881499/ https://www.ncbi.nlm.nih.gov/pubmed/29507125 http://dx.doi.org/10.1083/jcb.201707143

Ejemplares similares

Correction: IRE1–XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells
por: Tsuchiya, Yuichi, et al.
Publicado: (2019)

Novel mechanism of enhancing IRE1α-XBP1 signalling via the PERK-ATF4 pathway
por: Tsuru, Akio, et al.
Publicado: (2016)

Reconstitution and characterization of the unconventional splicing of XBP1u mRNA in vitro
por: Shinya, Sayoko, et al.
Publicado: (2011)

IRE1α Promotes Zika Virus Infection via XBP1
por: Kolpikova, Elena P., et al.
Publicado: (2020)

The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism
por: Roy, Anirban, et al.
Publicado: (2021)

IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin Level
por: Iwawaki, Takao, et al.
Publicado: (2010)

Transgenic mouse model exhibiting weak red fluorescence before and strong green fluorescence after Cre/loxP-mediated recombination
por: Akai, Ryoko, et al.
Publicado: (2020)

Role of IRE1α/XBP-1 in Cystic Fibrosis Airway Inflammation
por: Ribeiro, Carla M. P., et al.
Publicado: (2017)

IRE1α-XBP1 inhibitors exerted anti-tumor activities in Ewing’s sarcoma
por: Tanabe, Yu, et al.
Publicado: (2018)

Identification of a consensus element recognized and cleaved by IRE1α
por: Oikawa, Daisuke, et al.
Publicado: (2010)

The requirement of IRE1 and XBP1 in resolving physiological stress during Drosophila development
por: Huang, Huai-Wei, et al.
Publicado: (2017)

Pharmacologic IRE1/XBP1s Activation Confers Targeted ER Proteostasis Reprogramming
por: Grandjean, Julia M.D., et al.
Publicado: (2020)

The Role of BiP and the IRE1α–XBP1 Axis in Rhabdomyosarcoma Pathology
por: Aghaei, Mahmoud, et al.
Publicado: (2021)

Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity
por: Madhavan, Aparajita, et al.
Publicado: (2022)

Ebola Virus Activates IRE1α-Dependent XBP1u Splicing
por: Rohde, Cornelius, et al.
Publicado: (2022)

Ire1 Has Distinct Catalytic Mechanisms for XBP1/HAC1 Splicing and RIDD
por: Tam, Arvin B., et al.
Publicado: (2014)

Tight regulation of the unfolded protein sensor Ire1 by its intramolecularly antagonizing subdomain
por: Mathuranyanon, Rubwad, et al.
Publicado: (2015)

Retraction Note to: IRE1α-XBP1 but not PERK inhibition exerts anti-tumor activity in osteosarcoma
por: Sasa, Keita, et al.
Publicado: (2022)

RETRACTED ARTICLE: IRE1α-XBP1 but not PERK inhibition exerts anti-tumor activity in osteosarcoma
por: Sasa, Keita, et al.
Publicado: (2021)

Direct Association of Unfolded Proteins with Mammalian ER Stress Sensor, IRE1β
por: Oikawa, Daisuke, et al.
Publicado: (2012)

The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells
por: Hassler, Justin R., et al.
Publicado: (2015)

Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein Response
por: Jiang, Dadi, et al.
Publicado: (2016)

Pumilio protects Xbp1 mRNA from regulated Ire1-dependent decay
por: Cairrão, Fátima, et al.
Publicado: (2022)

Genomic targets of the IRE1-XBP1s pathway in mediating metabolic adaptation in epithelial plasticity
por: Qiao, Dianhua, et al.
Publicado: (2023)

The Role of IRE-XBP1 Pathway in Regulation of Retinal Pigment Epithelium Tight Junctions
por: Ma, Jacey H., et al.
Publicado: (2016)

Physiological IRE-1-XBP-1 and PEK-1 Signaling in Caenorhabditis elegans Larval Development and Immunity
por: Richardson, Claire E., et al.
Publicado: (2011)

Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer
por: Lin, Jianhuang, et al.
Publicado: (2021)

Role of IRE1α in podocyte proteostasis and mitochondrial health
por: Navarro-Betancourt, José R., et al.
Publicado: (2020)

Unfolded protein response mediator, the IRE1α-XBP1 pathway is involved in osteoblast differentiation
por: Tohmonda, Takahide, et al.
Publicado: (2012)

IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling
por: Sheng, Xia, et al.
Publicado: (2019)

IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity
por: Song, Minkyung, et al.
Publicado: (2018)

Mouse Hepatitis Virus Infection Activates the IRE1/XBP1 Pathway of the Unfolded Protein Response
por: Bechill, John, et al.
Publicado: (2006)

Bip-Yorkie interaction determines oncogenic and tumor-suppressive roles of Ire1/Xbp1s activation
por: Yang, Shuai, et al.
Publicado: (2022)

Enteroviruses Manipulate the Unfolded Protein Response through Multifaceted Deregulation of the Ire1-Xbp1 Pathway
por: Shishova, Anna, et al.
Publicado: (2022)

Obesity impacts placental function through activation of p-IRE1a-XBP1s signaling
por: Shen, Wei-Bin, et al.
Publicado: (2023)

The IRE1α-XBP1 Signaling Axis Promotes Glycolytic Reprogramming in Response to Inflammatory Stimuli
por: English, Bevin C., et al.
Publicado: (2022)

IRE1/XBP1 and endoplasmic reticulum signaling — from basic to translational research for cardiovascular disease
por: Fu, Fangyi, et al.
Publicado: (2022)

The unfolded protein response components IRE1α and XBP1 promote human coronavirus infection
por: Oda, Jessica M., et al.
Publicado: (2023)

Inhibition of IRE1α-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response
por: Chalmers, Fiona, et al.
Publicado: (2017)

IRE1α-XBP1 is a novel branch in the transcriptional regulation of Ucp1 in brown adipocytes
por: Asada, Rie, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_6tp3b5374ttchmr0nkdpahnb0l