Src-mediated phosphorylation converts FHL1 from tumor suppressor to tumor promoter

FHL1 has been recognized for a long time as a tumor suppressor protein that associates with both the actin cytoskeleton and the transcriptional machinery. We present in this study a paradigm that phosphorylated FHL1 functions as an oncogenic protein by promoting tumor cell proliferation. The cytosol...

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Detalles Bibliográficos
Autores principales: Wang, Xiang, Wei, Xiaofan, Yuan, Yang, Sun, Qingrui, Zhan, Jun, Zhang, Jing, Tang, Yan, Li, Feng, Ding, Lihua, Ye, Qinong, Zhang, Hongquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881501/
https://www.ncbi.nlm.nih.gov/pubmed/29434030
http://dx.doi.org/10.1083/jcb.201708064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881501/
https://www.ncbi.nlm.nih.gov/pubmed/29434030
http://dx.doi.org/10.1083/jcb.201708064

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