Doxycycline desensitization in chronic Q fever—A critical tool for the clinician

We present the case of a 45 year old woman with acute Q fever pneumonia who progressed to the chronic phase of the disease despite azithromycin therapy. A trial of doxycycline was halted because of severe allergy and she was put on clarithromycin and later moxifloxacin. Failure of both drugs require...

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Autores principales: Caplunik-Pratsch, Aila Luise, Potasman, Israel, Kessel, Aharon, Paz, Alona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881519/
https://www.ncbi.nlm.nih.gov/pubmed/29619325
http://dx.doi.org/10.1016/j.idcr.2018.01.006
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author Caplunik-Pratsch, Aila Luise
Potasman, Israel
Kessel, Aharon
Paz, Alona
author_facet Caplunik-Pratsch, Aila Luise
Potasman, Israel
Kessel, Aharon
Paz, Alona
author_sort Caplunik-Pratsch, Aila Luise
collection PubMed
description We present the case of a 45 year old woman with acute Q fever pneumonia who progressed to the chronic phase of the disease despite azithromycin therapy. A trial of doxycycline was halted because of severe allergy and she was put on clarithromycin and later moxifloxacin. Failure of both drugs required desensitization to doxycycline with escalating doses. After two-year treatment with doxycycline-hydroxychloroquine combination, complete recovery was declared. Our case highlights the option of doxycycline desensitization when an acute allergic reaction poses an obstacle to optimal treatment.
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spelling pubmed-58815192018-04-04 Doxycycline desensitization in chronic Q fever—A critical tool for the clinician Caplunik-Pratsch, Aila Luise Potasman, Israel Kessel, Aharon Paz, Alona IDCases Article We present the case of a 45 year old woman with acute Q fever pneumonia who progressed to the chronic phase of the disease despite azithromycin therapy. A trial of doxycycline was halted because of severe allergy and she was put on clarithromycin and later moxifloxacin. Failure of both drugs required desensitization to doxycycline with escalating doses. After two-year treatment with doxycycline-hydroxychloroquine combination, complete recovery was declared. Our case highlights the option of doxycycline desensitization when an acute allergic reaction poses an obstacle to optimal treatment. Elsevier 2018-02-20 /pmc/articles/PMC5881519/ /pubmed/29619325 http://dx.doi.org/10.1016/j.idcr.2018.01.006 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Caplunik-Pratsch, Aila Luise
Potasman, Israel
Kessel, Aharon
Paz, Alona
Doxycycline desensitization in chronic Q fever—A critical tool for the clinician
title Doxycycline desensitization in chronic Q fever—A critical tool for the clinician
title_full Doxycycline desensitization in chronic Q fever—A critical tool for the clinician
title_fullStr Doxycycline desensitization in chronic Q fever—A critical tool for the clinician
title_full_unstemmed Doxycycline desensitization in chronic Q fever—A critical tool for the clinician
title_short Doxycycline desensitization in chronic Q fever—A critical tool for the clinician
title_sort doxycycline desensitization in chronic q fever—a critical tool for the clinician
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881519/
https://www.ncbi.nlm.nih.gov/pubmed/29619325
http://dx.doi.org/10.1016/j.idcr.2018.01.006
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AT kesselaharon doxycyclinedesensitizationinchronicqfeveracriticaltoolfortheclinician
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