Kinetics and inhibition studies of the L205R mutant of cAMP‐dependent protein kinase involved in Cushing's syndrome

Overproduction of cortisol by the hypothalamus–pituitary–adrenal hormone system results in the clinical disorder known as Cushing's syndrome. Genomics studies have identified a key mutation (L205R) in the α‐isoform of the catalytic subunit of cAMP‐dependent protein kinase (PKACα) in adrenal ade...

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Detalles Bibliográficos
Autores principales: Luzi, Nicole M., Lyons, Charles E., Peterson, Darrell L., Ellis, Keith C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881547/
https://www.ncbi.nlm.nih.gov/pubmed/29632813
http://dx.doi.org/10.1002/2211-5463.12396

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881547/
https://www.ncbi.nlm.nih.gov/pubmed/29632813
http://dx.doi.org/10.1002/2211-5463.12396

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