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Kinetics and inhibition studies of the L205R mutant of cAMP‐dependent protein kinase involved in Cushing's syndrome
Overproduction of cortisol by the hypothalamus–pituitary–adrenal hormone system results in the clinical disorder known as Cushing's syndrome. Genomics studies have identified a key mutation (L205R) in the α‐isoform of the catalytic subunit of cAMP‐dependent protein kinase (PKACα) in adrenal ade...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881547/ https://www.ncbi.nlm.nih.gov/pubmed/29632813 http://dx.doi.org/10.1002/2211-5463.12396 |