Anti-MAdCAM Antibody Increases ß7+ T Cells and CCR9 Gene Expression in the Peripheral Blood of Patients With Crohn’s Disease

OBJECTIVE: To define pharmacodynamic biomarkers in the peripheral blood of patients with Crohn’s disease [CD] after treatment with PF-00547659, an anti-human mucosal addressin cell adhesion molecule-1 [MAdCAM-1] monoclonal antibody. METHODS: In this Phase 2, randomised, double-blind, controlled stud...

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Detalles Bibliográficos
Autores principales: Hassan-Zahraee, Mina, Banerjee, Anindita, Cheng, John B, Zhang, Weidong, Ahmad, Alaa, Page, Karen, von Schack, David, Zhang, Baohong, Martin, Steven W, Nayak, Satyaprakash, Reddy, Padma, Xi, Li, Neubert, Hendrik, Fernandez Ocana, Mireia, Gorelick, Ken, Clare, Robert, Vincent, Michael, Cataldi, Fabio, Hung, Kenneth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881777/
https://www.ncbi.nlm.nih.gov/pubmed/28961803
http://dx.doi.org/10.1093/ecco-jcc/jjx121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881777/
https://www.ncbi.nlm.nih.gov/pubmed/28961803
http://dx.doi.org/10.1093/ecco-jcc/jjx121

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