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Clostridium difficile Colitis Leading to Reactive Arthritis: A Rare Complication Associated With a Common Disease
The relationship between reactive arthritis and enteric infections caused by Yersinia enterocolitica, Campylobacter jejuni, and Salmonella typhimurium is well documented. Clostridium difficile colitis is a less recognized cause of reactive arthritis. We present a case of a 58-year-old woman with Clo...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881974/ https://www.ncbi.nlm.nih.gov/pubmed/29623279 http://dx.doi.org/10.1177/2324709618767689 |
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author | Marwat, Asghar Mehmood, Hassan Hussain, Ali Khan, Muzammil Ullah, Asad Joshi, Medha |
author_facet | Marwat, Asghar Mehmood, Hassan Hussain, Ali Khan, Muzammil Ullah, Asad Joshi, Medha |
author_sort | Marwat, Asghar |
collection | PubMed |
description | The relationship between reactive arthritis and enteric infections caused by Yersinia enterocolitica, Campylobacter jejuni, and Salmonella typhimurium is well documented. Clostridium difficile colitis is a less recognized cause of reactive arthritis. We present a case of a 58-year-old woman with Clostridium difficile colitis complicated by reactive arthritis. A 58-year-old woman with no significant past medical history presented to our hospital with complaints of nonbloody watery diarrhea, abdominal pain for the past 1 week, and right knee pain starting 1 day prior. The patient had recently used antibiotics for a respiratory tract infection. On examination, the patient had a swollen and erythematous right knee. While in the hospital the patient also developed a similarly painful and swollen left knee. The patient was found to be positive for C difficile toxin in stool. Synovial fluid analysis of both the knee joints revealed a sterile and inflammatory fluid, negative for crystals and showing no growth on gram stain. We diagnosed the patient with reactive arthritis secondary to C difficile colitis once all other causes of the bilateral knee joint symptoms were ruled out with appropriate laboratory and imaging studies. Treatment with oral vancomycin and an anti-inflammatory was initiated, and the patient had complete resolution of symptoms. This case illustrates the importance of recognizing C difficile colitis as a potential differential for reactive arthritis under the appropriate circumstances. The treatment of reactive arthritis is mainly supportive and treating the underlying cause, which happens to be C difficile in this case. |
format | Online Article Text |
id | pubmed-5881974 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-58819742018-04-05 Clostridium difficile Colitis Leading to Reactive Arthritis: A Rare Complication Associated With a Common Disease Marwat, Asghar Mehmood, Hassan Hussain, Ali Khan, Muzammil Ullah, Asad Joshi, Medha J Investig Med High Impact Case Rep Case Report The relationship between reactive arthritis and enteric infections caused by Yersinia enterocolitica, Campylobacter jejuni, and Salmonella typhimurium is well documented. Clostridium difficile colitis is a less recognized cause of reactive arthritis. We present a case of a 58-year-old woman with Clostridium difficile colitis complicated by reactive arthritis. A 58-year-old woman with no significant past medical history presented to our hospital with complaints of nonbloody watery diarrhea, abdominal pain for the past 1 week, and right knee pain starting 1 day prior. The patient had recently used antibiotics for a respiratory tract infection. On examination, the patient had a swollen and erythematous right knee. While in the hospital the patient also developed a similarly painful and swollen left knee. The patient was found to be positive for C difficile toxin in stool. Synovial fluid analysis of both the knee joints revealed a sterile and inflammatory fluid, negative for crystals and showing no growth on gram stain. We diagnosed the patient with reactive arthritis secondary to C difficile colitis once all other causes of the bilateral knee joint symptoms were ruled out with appropriate laboratory and imaging studies. Treatment with oral vancomycin and an anti-inflammatory was initiated, and the patient had complete resolution of symptoms. This case illustrates the importance of recognizing C difficile colitis as a potential differential for reactive arthritis under the appropriate circumstances. The treatment of reactive arthritis is mainly supportive and treating the underlying cause, which happens to be C difficile in this case. SAGE Publications 2018-03-30 /pmc/articles/PMC5881974/ /pubmed/29623279 http://dx.doi.org/10.1177/2324709618767689 Text en © 2018 American Federation for Medical Research http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Marwat, Asghar Mehmood, Hassan Hussain, Ali Khan, Muzammil Ullah, Asad Joshi, Medha Clostridium difficile Colitis Leading to Reactive Arthritis: A Rare Complication Associated With a Common Disease |
title | Clostridium difficile Colitis Leading to Reactive Arthritis: A Rare Complication Associated With a Common Disease |
title_full | Clostridium difficile Colitis Leading to Reactive Arthritis: A Rare Complication Associated With a Common Disease |
title_fullStr | Clostridium difficile Colitis Leading to Reactive Arthritis: A Rare Complication Associated With a Common Disease |
title_full_unstemmed | Clostridium difficile Colitis Leading to Reactive Arthritis: A Rare Complication Associated With a Common Disease |
title_short | Clostridium difficile Colitis Leading to Reactive Arthritis: A Rare Complication Associated With a Common Disease |
title_sort | clostridium difficile colitis leading to reactive arthritis: a rare complication associated with a common disease |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881974/ https://www.ncbi.nlm.nih.gov/pubmed/29623279 http://dx.doi.org/10.1177/2324709618767689 |
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