A novel calcimimetic agent, evocalcet (MT-4580/KHK7580), suppresses the parathyroid cell function with little effect on the gastrointestinal tract or CYP isozymes in vivo and in vitro

Cinacalcet hydrochloride (cinacalcet), an oral calcimimetic agent has been widely used for the management of secondary hyperparathyroidism (SHPT) in chronic kidney disease (CKD). In sharp contrast to vitamin D receptor activators, cinacalcet suppresses SHPT without inducing hypercalcemia or hyperpho...

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Detalles Bibliográficos
Autores principales: Kawata, Takehisa, Tokunaga, Shin, Murai, Miki, Masuda, Nami, Haruyama, Waka, Shoukei, Youji, Hisada, Yutaka, Yanagida, Tetsuya, Miyazaki, Hiroshi, Wada, Michihito, Akizawa, Tadao, Fukagawa, Masafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882164/
https://www.ncbi.nlm.nih.gov/pubmed/29614098
http://dx.doi.org/10.1371/journal.pone.0195316

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