PDZ domain-binding motif of Tax sustains T-cell proliferation in HTLV-1-infected humanized mice

Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia/lymphoma (ATLL), an aggressive malignant proliferation of activated CD4+ T lymphocytes. The viral Tax oncoprotein is critically involved in both HTLV-1-replication and T-cell proliferation, a prerequisite t...

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Detalles Bibliográficos
Autores principales: Pérès, Eléonore, Blin, Juliana, Ricci, Emiliano P., Artesi, Maria, Hahaut, Vincent, Van den Broeke, Anne, Corbin, Antoine, Gazzolo, Louis, Ratner, Lee, Jalinot, Pierre, Duc Dodon, Madeleine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882172/
https://www.ncbi.nlm.nih.gov/pubmed/29566098
http://dx.doi.org/10.1371/journal.ppat.1006933

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