Simplified Footprint-Free Cas9/CRISPR Editing of Cardiac-Associated Genes in Human Pluripotent Stem Cells

Modeling disease with human pluripotent stem cells (hPSCs) is hindered because the impact on cell phenotype from genetic variability between individuals can be greater than from the pathogenic mutation. While “footprint-free” Cas9/CRISPR editing solves this issue, existing approaches are inefficient...

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Detalles Bibliográficos
Autores principales: Kondrashov, Alexander, Hoang, Minh Duc, Smith, James G.W., Bhagwan, Jamie R., Duncan, Gary, Mosqueira, Diogo, Munoz, Maria Barbadillo, Vo, Nguyen T.N., Denning, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2018
Materias:
Original Research Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882176/
https://www.ncbi.nlm.nih.gov/pubmed/29402189
http://dx.doi.org/10.1089/scd.2017.0268

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