Functional roles of Mg(2+) binding sites in ion-dependent gating of a Mg(2+) channel, MgtE, revealed by solution NMR

Magnesium ions (Mg(2+)) are divalent cations essential for various cellular functions. Mg(2+) homeostasis is maintained through Mg(2+) channels such as MgtE, a prokaryotic Mg(2+) channel whose gating is regulated by intracellular Mg(2+) levels. Our previous crystal structure of MgtE in the Mg(2+)-bo...

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Detalles Bibliográficos
Autores principales: Maruyama, Tatsuro, Imai, Shunsuke, Kusakizako, Tsukasa, Hattori, Motoyuki, Ishitani, Ryuichiro, Nureki, Osamu, Ito, Koichi, Maturana, Andrès D, Shimada, Ichio, Osawa, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882242/
https://www.ncbi.nlm.nih.gov/pubmed/29611805
http://dx.doi.org/10.7554/eLife.31596

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