Recruitment of lysine demethylase 2A to DNA double strand breaks and its interaction with 53BP1 ensures genome stability

Lysine demethylase 2A (KDM2A) functions in transcription as a demethylase of lysine 36 on histone H3. Herein, we characterise a role for KDM2A in the DNA damage response in which KDM2A stimulates conjugation of ubiquitin to 53BP1. Impaired KDM2A-mediated ubiquitination negatively affects the recruit...

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Detalles Bibliográficos
Autores principales: Bueno, Murilo T.D., Baldascini, Marta, Richard, Stéphane, Lowndes, Noel F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882307/
https://www.ncbi.nlm.nih.gov/pubmed/29662616
http://dx.doi.org/10.18632/oncotarget.24636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882307/
https://www.ncbi.nlm.nih.gov/pubmed/29662616
http://dx.doi.org/10.18632/oncotarget.24636

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