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Recruitment of lysine demethylase 2A to DNA double strand breaks and its interaction with 53BP1 ensures genome stability

Lysine demethylase 2A (KDM2A) functions in transcription as a demethylase of lysine 36 on histone H3. Herein, we characterise a role for KDM2A in the DNA damage response in which KDM2A stimulates conjugation of ubiquitin to 53BP1. Impaired KDM2A-mediated ubiquitination negatively affects the recruit...

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Detalles Bibliográficos
Autores principales:	Bueno, Murilo T.D., Baldascini, Marta, Richard, Stéphane, Lowndes, Noel F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882307/ https://www.ncbi.nlm.nih.gov/pubmed/29662616 http://dx.doi.org/10.18632/oncotarget.24636

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