Type II RAF inhibitor causes superior ERK pathway suppression compared to type I RAF inhibitor in cells expressing different BRAF mutant types recurrently found in lung cancer

A large fraction of somatic driver BRAF mutations in lung cancer are non-V600 and impaired-kinase. Non-V600 BRAF mutations predict sensitivity to combination of a type I RAF inhibitor, Dabrafenib, and a MEK inhibitor, Trametinib. Singly, Dabrafenib only weakly suppresses mutant BRAF-induced ERK sign...

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Detalles Bibliográficos
Autores principales: Noeparast, Amir, Giron, Philippe, De Brakeleer, Sylvia, Eggermont, Carolien, De Ridder, Ulrike, Teugels, Erik, De Grève, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882321/
https://www.ncbi.nlm.nih.gov/pubmed/29662630
http://dx.doi.org/10.18632/oncotarget.24576

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