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CK1/Doubletime activity delays transcription activation in the circadian clock

In the Drosophila circadian clock, Period (PER) and Timeless (TIM) proteins inhibit Clock-mediated transcription of per and tim genes until PER is degraded by Doubletime/CK1 (DBT)-mediated phosphorylation, establishing a negative feedback loop. Multiple regulatory delays within this feedback loop en...

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Detalles Bibliográficos
Autores principales:	Top, Deniz, O'Neil, Jenna L, Merz, Gregory E, Dusad, Kritika, Crane, Brian R, Young, Michael W
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882363/ https://www.ncbi.nlm.nih.gov/pubmed/29611807 http://dx.doi.org/10.7554/eLife.32679

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