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Anti-inflammatory monocytes—interplay of innate and adaptive immunity

Monocytes are central to our health as they contribute to both hemispheres of our immune system, the innate and the adaptive arm. Sensing signals from the outside world, monocytes govern the innate immunity by initiating inflammation, e.g., through production of IL-1β. Uncontrolled and sustained inf...

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Detalles Bibliográficos
Autores principales: Varga, Georg, Foell, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882470/
https://www.ncbi.nlm.nih.gov/pubmed/29616417
http://dx.doi.org/10.1186/s40348-018-0083-4
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author Varga, Georg
Foell, Dirk
author_facet Varga, Georg
Foell, Dirk
author_sort Varga, Georg
collection PubMed
description Monocytes are central to our health as they contribute to both hemispheres of our immune system, the innate and the adaptive arm. Sensing signals from the outside world, monocytes govern the innate immunity by initiating inflammation, e.g., through production of IL-1β. Uncontrolled and sustained inflammation, however, leads to auto-inflammatory syndromes and sometimes to autoimmune diseases. Monocytes can be a driving force for the establishment of such diseases when their ability to also contribute to the resolution of inflammation is impaired. It is therefore of vast importance to gain knowledge about the anti-inflammatory mechanisms monocytes can use to participate in downregulation and resolution of inflammation. Here, we summarize some of the known anti-inflammatory mechanisms and features of regulatory monocytes and shed light on their importance in governing innate and adaptive immune responses. Considering anti-inflammatory mechanisms of monocytes will also help to develop new strategies to use monocytes as therapeutic targets in the future.
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spelling pubmed-58824702018-04-11 Anti-inflammatory monocytes—interplay of innate and adaptive immunity Varga, Georg Foell, Dirk Mol Cell Pediatr Mini Review Monocytes are central to our health as they contribute to both hemispheres of our immune system, the innate and the adaptive arm. Sensing signals from the outside world, monocytes govern the innate immunity by initiating inflammation, e.g., through production of IL-1β. Uncontrolled and sustained inflammation, however, leads to auto-inflammatory syndromes and sometimes to autoimmune diseases. Monocytes can be a driving force for the establishment of such diseases when their ability to also contribute to the resolution of inflammation is impaired. It is therefore of vast importance to gain knowledge about the anti-inflammatory mechanisms monocytes can use to participate in downregulation and resolution of inflammation. Here, we summarize some of the known anti-inflammatory mechanisms and features of regulatory monocytes and shed light on their importance in governing innate and adaptive immune responses. Considering anti-inflammatory mechanisms of monocytes will also help to develop new strategies to use monocytes as therapeutic targets in the future. Springer Berlin Heidelberg 2018-04-03 /pmc/articles/PMC5882470/ /pubmed/29616417 http://dx.doi.org/10.1186/s40348-018-0083-4 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Mini Review
Varga, Georg
Foell, Dirk
Anti-inflammatory monocytes—interplay of innate and adaptive immunity
title Anti-inflammatory monocytes—interplay of innate and adaptive immunity
title_full Anti-inflammatory monocytes—interplay of innate and adaptive immunity
title_fullStr Anti-inflammatory monocytes—interplay of innate and adaptive immunity
title_full_unstemmed Anti-inflammatory monocytes—interplay of innate and adaptive immunity
title_short Anti-inflammatory monocytes—interplay of innate and adaptive immunity
title_sort anti-inflammatory monocytes—interplay of innate and adaptive immunity
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882470/
https://www.ncbi.nlm.nih.gov/pubmed/29616417
http://dx.doi.org/10.1186/s40348-018-0083-4
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