Cytochrome b(5) impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b(5)/P450 reductase null (HBRN) mice

Benzo[a]pyrene (BaP) is an environmental pollutant that, based on evidence largely from in vitro studies, exerts its genotoxic effects after metabolic activation by cytochrome P450s. In the present study, Hepatic Reductase Null (HRN) and Hepatic Cytochrome b(5)/P450 Reductase Null (HBRN) mice have b...

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Detalles Bibliográficos
Autores principales: Reed, Lindsay, Mrizova, Iveta, Barta, Frantisek, Indra, Radek, Moserova, Michaela, Kopka, Klaus, Schmeiser, Heinz H., Wolf, C. Roland, Henderson, Colin J., Stiborova, Marie, Phillips, David H., Arlt, Volker M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Genotoxicity and Carcinogenicity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882632/
https://www.ncbi.nlm.nih.gov/pubmed/29368147
http://dx.doi.org/10.1007/s00204-018-2162-7

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