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Affinity maturation of humanized anti-epidermal growth factor receptor antibody using a modified phage-based open sandwich selection method

Affinity maturation is one of the cardinal strategies for improving antibody function using in vitro evolutionary methods; one such well-established method is phage display. To minimise gene deletion, we previously developed an open sandwich (OS) method wherein selection was performed using only pha...

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Detalles Bibliográficos
Autores principales:	Sanada, Hideaki, Kobayashi, Kazuki, Oyama, Kenji, Maru, Takamitsu, Nakanishi, Takeshi, Umetsu, Mitsuo, Asano, Ryutaro, Kumagai, Izumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882652/ https://www.ncbi.nlm.nih.gov/pubmed/29615700 http://dx.doi.org/10.1038/s41598-018-23796-3

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